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PMID: 18347069 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

As functional nuclear actin comes into view, is it globular, filamentous, or both?

The Journal of cell biology ·Vol. 180 ·No. 6 ·2008-03-24 ·Pages 1061-4

Pederson T

Abstract

The idea that actin may have an important function in the nucleus has undergone a rapid transition from one greeted with skepticism to a now rapidly advancing research field. Actin has now been implicated in transcription by all three RNA polymerases, but the structural form it adopts in these processes remains unclear. Recently, a claim was made that monomeric nuclear actin plays a role in signal transduction, while a just-published study of RNA polymerase I transcription has implicated polymeric actin, consorting with an isoform of its classical partner myosin. Both studies are critically discussed here, and although there are several issues to be resolved, it now seems reasonable to start thinking about functions for both monomeric and assembled actin in the nucleus.

MeSH Terms
Actin Cytoskeleton/genetics,metabolism,ultrastructure Actins/genetics,metabolism,ultrastructure Animals Cell Nucleolus/genetics,metabolism,ultrastructure Cell Nucleus/genetics,metabolism,ultrastructure Humans Polymers/metabolism RNA Polymerase I/genetics,metabolism RNA, Ribosomal/biosynthesis,genetics
Chemicals
Actins Polymers RNA, Ribosomal RNA Polymerase I
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Pederson Thoru
Program in Cell Dynamics, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. [email protected]
References (37)
37 references, click to expand
  1. The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization.
    Mol Biol Cell. 2002 Nov;13(11):4088-99 PMID: 12429848
  2. Long-range directional movement of an interphase chromosome site.
    Curr Biol. 2006 Apr 18;16(8):825-31 PMID: 16631592
  3. Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.
    Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2824-9 PMID: 11880634
  4. Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor.
    Mol Biol Cell. 2002 Dec;13(12):4167-78 PMID: 12475943
  5. Searching for a function for nuclear actin.
    Trends Cell Biol. 2000 Mar;10(3):92-7 PMID: 10675902
  6. A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes.
    Nat Cell Biol. 2006 Mar;8(3):257-63 PMID: 16489345
  7. Actin' together: serum response factor, its cofactors and the link to signal transduction.
    Trends Cell Biol. 2006 Nov;16(11):588-96 PMID: 17035020
  8. Nuclear actin extends, with no contraction in sight.
    Mol Biol Cell. 2005 Nov;16(11):5055-60 PMID: 16148048
  9. Molecular functions of nuclear actin in transcription.
    J Cell Biol. 2006 Mar 27;172(7):967-71 PMID: 16549500
  10. Actin in transcription and transcription regulation.
    Curr Opin Cell Biol. 2006 Jun;18(3):261-6 PMID: 16687246
  11. Evolution of the cytoskeleton.
    Bioessays. 2007 Jul;29(7):668-77 PMID: 17563102
  12. Actin- and protein-4.1-containing filaments link nuclear pore complexes to subnuclear organelles in Xenopus oocyte nuclei.
    J Cell Sci. 2004 May 15;117(Pt 12):2481-90 PMID: 15128868
  13. Nuclear actin and actin-related proteins in chromatin remodeling.
    Annu Rev Biochem. 2002;71:755-81 PMID: 12045110
  14. Review: movement of mRNA from transcription site to nuclear pores.
    J Struct Biol. 2000 Apr;129(2-3):252-7 PMID: 10806075
  15. Diffusion-based transport of nascent ribosomes in the nucleus.
    Mol Biol Cell. 2003 Dec;14(12):4805-12 PMID: 12960421
  16. Nucleoplasmic beta-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations.
    J Cell Biol. 2006 Feb 13;172(4):541-52 PMID: 16476775
  17. Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein.
    EMBO J. 1998 Mar 16;17(6):1635-41 PMID: 9501085
  18. Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle.
    Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17795-800 PMID: 17978175
  19. LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics.
    J Cell Biol. 2002 May 27;157(5):831-8 PMID: 12034774
  20. The growing pre-mRNA recruits actin and chromatin-modifying factors to transcriptionally active genes.
    Genes Dev. 2005 Aug 15;19(16):1871-84 PMID: 16103215
  21. Actin dynamics control SRF activity by regulation of its coactivator MAL.
    Cell. 2003 May 2;113(3):329-42 PMID: 12732141
  22. Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.
    Cell. 1998 Nov 25;95(5):625-36 PMID: 9845365
  23. Actin-dependent intranuclear repositioning of an active gene locus in vivo.
    J Cell Biol. 2007 Dec 17;179(6):1095-103 PMID: 18070915
  24. Dynamic instability in a DNA-segregating prokaryotic actin homolog.
    Science. 2004 Nov 5;306(5698):1021-5 PMID: 15528442
  25. An actin-ribonucleoprotein interaction is involved in transcription by RNA polymerase II.
    Proc Natl Acad Sci U S A. 2003 May 27;100(11):6475-80 PMID: 12743363
  26. The spandrels of San Marco and the Panglossian paradigm: a critique of the adaptationist programme.
    Proc R Soc Lond B Biol Sci. 1979 Sep 21;205(1161):581-98 PMID: 42062
  27. Nuclear actin and myosin I are required for RNA polymerase I transcription.
    Nat Cell Biol. 2004 Dec;6(12):1165-72 PMID: 15558034
  28. Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL.
    EMBO J. 2004 Oct 13;23(20):3973-83 PMID: 15385960
  29. An actin filament matrix in hand-isolated nuclei of X. laevis oocytes.
    Cell. 1979 Dec;18(4):1101-8 PMID: 574804
  30. Actin in the nucleus: what form and what for?
    J Struct Biol. 2002 Oct-Dec;140(1-3):3-9 PMID: 12490148
  31. Actin-based modeling of a transcriptionally competent nuclear substructure induced by transcription inhibition.
    Exp Cell Res. 2006 Nov 15;312(19):3796-807 PMID: 17022973
  32. Diffusible and bound actin nuclei of Xenopus laevis oocytes.
    Cell. 1977 Dec;12(4):883-91 PMID: 563771
  33. Exporting actin.
    Nat Cell Biol. 2006 Mar;8(3):205-7 PMID: 16508670
  34. Nuclear myosin I acts in concert with polymeric actin to drive RNA polymerase I transcription.
    Genes Dev. 2008 Feb 1;22(3):322-30 PMID: 18230700
  35. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.
    Science. 2007 Jun 22;316(5832):1749-52 PMID: 17588931
  36. The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.
    EMBO Rep. 2006 May;7(5):525-30 PMID: 16514417
  37. Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium.
    Curr Biol. 2007 Sep 4;17(17):R757-9 PMID: 17803924
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
DOI
10.1083/jcb.200709082
Email
[email protected]
Published
2008-03-24
Epub
2008-00-17
Pages
1061-4
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2290836
Subset
IM
External Links
PubMed source DOI: 10.1083/jcb.200709082 PMC Full Text View journal details
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