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PMID: 18384642 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease.

Journal of neurochemistry ·Vol. 106 ·No. 1 ·2008-07-00 ·Pages 24-36

Sulzer D, Mosharov E, Talloczy Z, Zucca FA, Simon JD, Zecca L

Abstract

The most striking morphologic change in neurons during normal aging is the accumulation of autophagic vacuoles filled with lipofuscin or neuromelanin pigments. These organelles are similar to those containing the ceroid pigments associated with neurologic disorders, particularly in diseases caused by lysosomal dysfunction. The pigments arise from incompletely degraded proteins and lipids principally derived from the breakdown of mitochondria or products of oxidized catecholamines. Pigmented autophagic vacuoles may eventually occupy a major portion of the neuronal cell body volume because of resistance of the pigments to lysosomal degradation and/or inadequate fusion of the vacuoles with lysosomes. Although the formation of autophagic vacuoles via macroautophagy protects the neuron from cellular stress, accumulation of pigmented autophagic vacuoles may eventually interfere with normal degradative pathways and endocytic/secretory tasks such as appropriate response to growth factors.

MeSH Terms
Aging/metabolism Animals Autophagy/physiology Brain/metabolism,pathology,ultrastructure Brain Diseases/metabolism,pathology Ceroid/metabolism Coloring Agents/metabolism Humans Lipofuscin/metabolism Melanins/metabolism Neurons/metabolism,pathology,ultrastructure Vacuoles/metabolism,pathology,ultrastructure
Chemicals
Ceroid Coloring Agents Lipofuscin Melanins neuromelanin
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sulzer David
Department of Neurology, Columbia University, New York, NY 10036, USA. [email protected]
Mosharov Eugene
Talloczy Zsolt
Zucca Fabio A
Simon John D
Zecca Luigi
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Article Info
Journal
Journal of neurochemistry
Abbr.
J Neurochem
ISSN
1471-4159
DOI
10.1111/j.1471-4159.2008.05385.x
Email
[email protected]
Published
2008-07-00
Epub
2008-00-01
Pages
24-36
Language
English
Region
England
NLM ID
2985190R
PMCID
PMC6609458
Subset
IM
Grants
NINDS NIH HHS · P50 NS038370 · United States
External Links
PubMed source DOI: 10.1111/j.1471-4159.2008.05385.x PMC Full Text View journal details
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