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PMID: 18395701 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

The role of the cerebellum in schizophrenia.

Biological psychiatry ·Vol. 64 ·No. 2 ·2008-07-15 ·Pages 81-8

Andreasen NC, Pierson R

Abstract

For many years the cerebellum has been considered to serve as a coordinator of motor function. Likewise, for many years schizophrenia has been considered to be a disease that primarily affects the cerebrum. This review summarizes recent evidence that both these views must be revised in the light of emerging evidence about cerebellar function and the mechanisms of schizophrenia. Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized. Evidence indicating that cerebellar abnormalities occur in schizophrenia is also reviewed. These suggest interesting directions for future research.

MeSH Terms
Brain Mapping Cerebellum/physiopathology Cerebral Cortex/physiopathology Cognition Disorders/physiopathology,psychology Higher Nervous Activity/physiology Humans Long-Term Potentiation/physiology Nerve Net/physiopathology Neuropsychological Tests Olivary Nucleus/physiopathology Pons/physiopathology Positron-Emission Tomography Psychiatric Status Rating Scales Psychomotor Performance/physiology Schizophrenia/physiopathology Schizophrenic Psychology Thalamus/physiopathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Andreasen Nancy C
Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA. [email protected]
Pierson Ronald
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Article Info
Journal
Biological psychiatry
Abbr.
Biol Psychiatry
ISSN
1873-2402
DOI
10.1016/j.biopsych.2008.01.003
Email
[email protected]
Published
2008-07-15
Epub
2008-00-08
Pages
81-8
Language
English
Region
United States
NLM ID
0213264
PMCID
PMC3175494
Subset
IM
Grants
NIMH NIH HHS · 5 R01 MH 04856-20 · United States
NIMH NIH HHS · R01 MH060990 · United States
NIMH NIH HHS · R01 MH040856-21 · United States
NIMH NIH HHS · R01 MH040856 · United States
NIMH NIH HHS · 5 R01 MH060990-09 · United States
External Links
PubMed source DOI: 10.1016/j.biopsych.2008.01.003 PMC Full Text View journal details
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