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PMID: 18400207 Published · ppublish English Consensus Development Conference, NIH Journal Article Research Support, N.I.H., Extramural

The cognitive neuroscience of working memory: relevance to CNTRICS and schizophrenia.

Biological psychiatry ·Vol. 64 ·No. 1 ·2008-07-01 ·Pages 11-7

Barch DM, Smith E

Abstract

Working memory is one of the central constructs in cognitive science and has received enormous attention in the theoretical and empirical literature. Similarly, working memory deficits have long been thought to be among the core cognitive deficits in schizophrenia, making it a ripe area for translation. This article provides a brief overview of the current theories and data on the psychological and neural mechanisms involved in working memory, which is a summary of the presentation and discussion on working memory that occurred at the first Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) meeting (Washington, D.C.). At this meeting, the consensus was that the constructs of goal maintenance and interference control were the most ready to be pursued as part of a translational cognitive neuroscience effort at future CNTRICS meetings. The constructs of long-term memory reactivation, capacity, and strategic encoding were felt to be of great clinical interest but requiring more basic research. In addition, the group felt that the constructs of maintenance over time and updating in working memory had growing construct validity at the psychological and neural levels but required more research in schizophrenia before these should be considered as targets for a clinical trials setting.

MeSH Terms
Antipsychotic Agents/therapeutic use Biomedical Research Cognition Disorders/drug therapy,physiopathology Cooperative Behavior Drug Industry Frontal Lobe/drug effects,physiopathology Humans Memory Disorders/drug therapy,physiopathology Memory, Short-Term/drug effects,physiology National Institute of Mental Health (U.S.) Prefrontal Cortex/drug effects,physiopathology Retention, Psychology/drug effects,physiology Schizophrenia/diagnosis,drug therapy,physiopathology Schizophrenic Psychology Temporal Lobe/drug effects,physiopathology United States United States Food and Drug Administration
Chemicals
Antipsychotic Agents
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Barch Deanna M
Department of Psychology, Washington University, St. Louis, MO 63130, USA. [email protected]
Smith Ed
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Article Info
Journal
Biological psychiatry
Abbr.
Biol Psychiatry
ISSN
1873-2402
DOI
10.1016/j.biopsych.2008.03.003
Email
[email protected]
Published
2008-07-01
Epub
2008-00-08
Pages
11-7
Language
English
Region
United States
NLM ID
0213264
PMCID
PMC2483314
Subset
IM
Grants
NIMH NIH HHS · R01 MH056584 · United States
NIMH NIH HHS · R13 MH078710 · United States
NIMH NIH HHS · R01 MH066031 · United States
NIMH NIH HHS · MH56584 · United States
NIMH NIH HHS · R13 MH078710-02 · United States
NIMH NIH HHS · P50 MH071616 · United States
NIMH NIH HHS · MH071616 · United States
NIMH NIH HHS · MH066031 · United States
NIMH NIH HHS · MH60887 · United States
External Links
PubMed source DOI: 10.1016/j.biopsych.2008.03.003 PMC Full Text View journal details
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