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PMID: 18417336 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Cytokine-producing B lymphocytes-key regulators of immunity.

Current opinion in immunology ·Vol. 20 ·No. 3 ·2008-06-00 ·Pages 332-8

Lund FE

Abstract

The successful use of B cell depletion therapy for the treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators of immunity. However, to the surprise of many, B cells appear to regulate autoimmune conditions independently of their ability to produce autoantibodies. Indeed, disturbances in the ability of B cell subsets to present antigen, produce cytokines, and regulate the activities of T cells is emerging as a key feature in many inflammatory diseases. Here we review the recent literature describing cytokine-producing regulatory and effector B cell subsets in health and disease and discuss how future B cell-directed therapies might target the pathologic cytokine-producing effector B cell subsets without impacting the protective regulatory subsets.

MeSH Terms
Animals Autoimmunity B-Lymphocyte Subsets/immunology Cytokines/biosynthesis,physiology Humans Immunologic Memory Mice Models, Immunological
Chemicals
Cytokines
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lund Frances E
Trudeau Institute, Saranac Lake, NY 12983, USA. [email protected]
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
Published
2008-06-00
Epub
2008-00-15
Pages
332-8
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2474694
Subset
IM
Grants
NIAID NIH HHS · R01 AI050844-05 · United States
NIAID NIH HHS · R01 AI068056-03 · United States
NIAID NIH HHS · R01 AI068056 · United States
NIAID NIH HHS · R01-AI0688056 · United States
NIAID NIH HHS · R01 AI050844 · United States
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