Home LiteratureArticle Details
PMID: 18423194 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

miRiad roles for the miR-17-92 cluster in development and disease.

Cell ·Vol. 133 ·No. 2 ·2008-04-18 ·Pages 217-22

Mendell JT

Abstract

MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

MeSH Terms
Animals Embryo, Mammalian/metabolism Heart/embryology Humans Immune System/embryology Lung/embryology Mice MicroRNAs/genetics,metabolism Multigene Family Oncogenes RNA, Neoplasm/genetics,metabolism
Chemicals
MIRN17 microRNA, human MicroRNAs RNA, Neoplasm
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mendell Joshua T
McKusick-Nathans Institute of Genetic Medicine, Departments of Pediatrics and Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. [email protected]
References (24)
24 references, click to expand
  1. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage.
    Cell. 2008 Mar 7;132(5):860-74 PMID: 18329371
  2. Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors.
    J Biol Chem. 2007 Jan 26;282(4):2130-4 PMID: 17135268
  3. microRNAs exhibit high frequency genomic alterations in human cancer.
    Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9136-41 PMID: 16754881
  4. Activation of an oncogenic microRNA cistron by provirus integration.
    Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18680-4 PMID: 17121985
  5. A microRNA polycistron as a potential human oncogene.
    Nature. 2005 Jun 9;435(7043):828-33 PMID: 15944707
  6. Small non-coding RNAs in animal development.
    Nat Rev Mol Cell Biol. 2008 Mar;9(3):219-30 PMID: 18270516
  7. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.
    Cancer Cell. 2008 Mar;13(3):272-86 PMID: 18328430
  8. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
    Cancer Res. 2004 May 1;64(9):3087-95 PMID: 15126345
  9. c-Myc-regulated microRNAs modulate E2F1 expression.
    Nature. 2005 Jun 9;435(7043):839-43 PMID: 15944709
  10. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation.
    Nat Cell Biol. 2007 Jul;9(7):775-87 PMID: 17589498
  11. Retroviral insertional activation of the Fli-3 locus in erythroleukemias encoding a cluster of microRNAs that convert Epo-induced differentiation to proliferation.
    Blood. 2007 Oct 1;110(7):2631-40 PMID: 17586726
  12. Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.
    Cancer Res. 2007 Jun 15;67(12):5699-707 PMID: 17575136
  13. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA.
    Mol Cell Biol. 2006 Nov;26(21):8191-201 PMID: 16940181
  14. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
    Mol Cell Biol. 2008 Apr;28(7):2167-74 PMID: 18212054
  15. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes.
    Nat Immunol. 2008 Apr;9(4):405-14 PMID: 18327259
  16. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.
    Cell. 2008 Mar 7;132(5):875-86 PMID: 18329372
  17. A microRNA expression signature of human solid tumors defines cancer gene targets.
    Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 PMID: 16461460
  18. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
    Nat Genet. 2006 Sep;38(9):1060-5 PMID: 16878133
  19. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
    Mol Cell Biol. 2001 Dec;21(24):8547-64 PMID: 11713289
  20. An E2F/miR-20a autoregulatory feedback loop.
    J Biol Chem. 2007 Jan 26;282(4):2135-43 PMID: 17135249
  21. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells.
    Dev Biol. 2007 Oct 15;310(2):442-53 PMID: 17765889
  22. Prediction of mammalian microRNA targets.
    Cell. 2003 Dec 26;115(7):787-98 PMID: 14697198
  23. Bim is a suppressor of Myc-induced mouse B cell leukemia.
    Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6164-9 PMID: 15079075
  24. Repeat organization and epigenetic regulation of the DH-Cmu domain of the immunoglobulin heavy-chain gene locus.
    Mol Cell. 2007 Sep 7;27(5):842-50 PMID: 17803947
Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2008.04.001
Email
[email protected]
Published
2008-04-18
Pages
217-22
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2732113
Subset
IM
Grants
NCI NIH HHS · R01 CA120185 · United States
NCI NIH HHS · R01 CA120185-01A2 · United States
NCI NIH HHS · R01 CA120185-02 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2008.04.001 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2