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PMID: 18451103 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Genes & development ·Vol. 22 ·No. 9 ·2008-05-01 ·Pages 1115-40

Cloos PA, Christensen J, Agger K, Helin K

Abstract

The enzymes catalyzing lysine and arginine methylation of histones are essential for maintaining transcriptional programs and determining cell fate and identity. Until recently, histone methylation was regarded irreversible. However, within the last few years, several families of histone demethylases erasing methyl marks associated with gene repression or activation have been identified, underscoring the plasticity and dynamic nature of histone methylation. Recent discoveries have revealed that histone demethylases take part in large multiprotein complexes synergizing with histone deacetylases, histone methyltransferases, and nuclear receptors to control developmental and transcriptional programs. Here we review the emerging biochemical and biological functions of the histone demethylases and discuss their potential involvement in human diseases, including cancer.

MeSH Terms
Aging Animals Cell Differentiation Histones/metabolism Humans Methylation Models, Biological Neoplasms/metabolism,pathology Oxidoreductases, N-Demethylating/classification,metabolism Phylogeny
Chemicals
Histones Oxidoreductases, N-Demethylating
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cloos Paul A C
Biotech Research and Innovation Centre, University of Copenhagen, DK-2200 Copenhagen, Denmark. [email protected]
Christensen Jesper
Agger Karl
Helin Kristian
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
0890-9369
DOI
10.1101/gad.1652908
Email
[email protected]
Published
2008-05-01
Pages
1115-40
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2732404
Subset
IM
External Links
PubMed source DOI: 10.1101/gad.1652908 PMC Full Text View journal details
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