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PMID: 18495087 Published · ppublish English Consensus Development Conference, NIH Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

The cognitive neuroscience of memory function and dysfunction in schizophrenia.

Biological psychiatry ·Vol. 64 ·No. 1 ·2008-07-01 ·Pages 18-25

Ranganath C, Minzenberg MJ, Ragland JD

Abstract

Patients with schizophrenia have pronounced deficits in memory for events--episodic memory. These deficits severely affect patients' quality of life and functional outcome, and current medications have only a modest effect, making episodic memory an important domain for translational development of clinical trial paradigms. The current article provides a brief review of the significant progress that cognitive neuroscience has made in understanding basic mechanisms of episodic memory formation and retrieval that were presented and discussed at the first CNTRICS (Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia) meeting in Washington, D.C. During that meeting a collaborative decision was made that measures of item-specific and relational memory were the most promising constructs for immediate translational development. A brief summary of research on episodic memory in schizophrenia is presented to provide a context for investigating item-specific and relational memory processes. Candidate brain regions are also discussed.

MeSH Terms
Animals Brain Mapping Cognition Disorders/drug therapy,physiopathology,psychology Cooperative Behavior Dominance, Cerebral/physiology Humans Memory Disorders/drug therapy,physiopathology,psychology Memory, Short-Term/drug effects,physiology Neuropsychological Tests Prefrontal Cortex/drug effects,physiopathology Retention, Psychology/drug effects,physiology Schizophrenia/diagnosis,drug therapy,physiopathology Schizophrenic Psychology Temporal Lobe/drug effects,physiopathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ranganath Charan
Center for Neuroscience and Department of Psychology, University of California at Davis, Davis, CA 95618, USA. [email protected]
Minzenberg Michael J
Ragland J Daniel
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Article Info
Journal
Biological psychiatry
Abbr.
Biol Psychiatry
ISSN
1873-2402
DOI
10.1016/j.biopsych.2008.04.011
Email
[email protected]
Published
2008-07-01
Epub
2008-00-21
Pages
18-25
Language
English
Region
United States
NLM ID
0213264
PMCID
PMC2474810
Subset
IM
Grants
NIMH NIH HHS · R01 MH068721-04 · United States
NIMH NIH HHS · 1R01MH68721 · United States
NIMH NIH HHS · R01 MH068721-03 · United States
NIMH NIH HHS · R01 MH084895 · United States
NIMH NIH HHS · R01 MH068721 · United States
External Links
PubMed source DOI: 10.1016/j.biopsych.2008.04.011 PMC Full Text View journal details
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