Viral spread in the presence of neutralizing antibody: mechanisms of persistence in foamy virus infection.

Infection and immunity ·Vol. 14 ·No. 5 ·1976-11-00 ·Pages 1172-8

Hooks JJ, Burns W, Hayashi K, Geis S, Notkins AL

Abstract

Several viruses were categorized on the basis of their ability to spread from cell to contiguous cell and form plaques in the presence of antiviral antibody. Herpes simplex virus, cytomegalovirus, and vaccinia, measles, and foamy viruses were able to spread in the presence of neutralizing antibody, whereas coxsackievirus, encephalomyocarditis virus, vesicular stomatitis virus, mumps virus, and simian virus 5 failed to spread. A detailed study of one of these virus groups (simian foamy viruses) suggested that the ability of these viruses to spread from cell to cell in the presence of antiviral antibody, the failure of antiviral antibody and complement to lyse infected cells, and the poor induction and relative resistance of these viruses to the antiviral action of interferon contribute to the persistent nature of this infection.

MeSH Terms

Antibodies, Viral Complement System Proteins Cytotoxicity Tests, Immunologic Interferons/analysis Neutralization Tests RNA Viruses/growth & development Spumavirus/growth & development Time Factors Viral Plaque Assay Virus Diseases/immunology

Chemicals

Antibodies, Viral Complement System Proteins Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hooks J J

Burns W

Hayashi K

Geis S

Notkins A L

References (12)

12 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.14.5.1172-1178.1976

Published

1976-11-00

Pages

1172-8

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC415510

Subset

External Links

PubMed source DOI: 10.1128/iai.14.5.1172-1178.1976 PMC Full Text View journal details

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Viral spread in the presence of neutralizing antibody: mechanisms of persistence in foamy virus infection.

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