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PMID: 18563640 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Exploring the origins of the normal prostate and prostate cancer stem cell.

Stem cell reviews ·Vol. 4 ·No. 3 ·2008-09-00 ·Pages 193-201

Kasper S

Abstract

Prostate epithelial stem cells (PSCs) are primed by the urogenital mesenchyme to initiate bud formation and branching morphogenesis, ultimately culminating in a glandular structure composed of luminal, basal and neuroendocrine cells. Identity of this cell has remained elusive however cell populations enriched for cells exhibiting stem cell characteristics express the stem cell markers CD133(+), alpha2beta1(hi), CD44 and Sca-1 along with embryonic stem cell factors including Oct-1, Nanog, Sox2 and nestin. Androgens are critical to prostate organogenesis and play a major role in normal prostate function and the development of prostate cancer. Cell lineage is another variable in the development of prostate cancer. This review discusses the embryonic prostate stem cell niche, normal prostate development, isolation and characterization of normal prostate and prostate cancer stem cells, and current concepts on the origin of prostate cancer.

MeSH Terms
Cell Lineage Humans Male Models, Biological Neoplastic Stem Cells/metabolism,pathology Prostate/cytology,metabolism Prostatic Neoplasms/metabolism,pathology Stem Cells/cytology,metabolism
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kasper Susan
Department of Urologic Surgery, A-1302 Medical Center North, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232-2765, USA. [email protected]
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Article Info
Journal
Stem cell reviews
Abbr.
Stem Cell Rev
ISSN
1558-6804
DOI
10.1007/s12015-008-9033-1
Email
[email protected]
Published
2008-09-00
Pages
193-201
Language
English
Region
United States
NLM ID
101255952
Subset
IM
Grants
NIDDK NIH HHS · R01DK60957 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.1007/s12015-008-9033-1
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