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PMID: 15886883 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Stem/progenitor cells in mouse mammary gland development and breast cancer.

Journal of mammary gland biology and neoplasia ·Vol. 10 ·No. 1 ·2005-01-00 ·Pages 17-24

Li Y, Rosen JM

Abstract

Breast cancer is a genetically and clinically heterogeneous disease. It is unclear whether different target cells contribute to this heterogeneity and which cell types are most susceptible to oncogenesis. Stem cells are speculated to be the cellular origin of at least a subset of human breast cancers. To begin to address these issues, we have isolated and characterized cell populations enriched in normal mammary stem/progenitors and have studied the expression of putative stem/progenitor markers in tumors derived from genetically engineered mice. Specifically, transgenic activation of Wnt signaling in the mammary gland induces tumors comprised of epithelial and myoepithelial cells harboring the same genetic defect implying that the tumor arose from transformation of a bipotent progenitor cell. On the other hand, transgenic activation of Neu signaling induces tumors comprising cells of more limited lineage capacity. Thus, the heterogeneity of different breast cancers may reflect the activation of different oncogenic pathways, different cellular targets in which these genetic changes occur, or both.

MeSH Terms
Animals Breast Neoplasms/metabolism,pathology Cell Differentiation Cell Transformation, Neoplastic Humans Mammary Glands, Animal/growth & development,metabolism,pathology Mice Stem Cells/cytology,metabolism,pathology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Li Yi
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Rosen Jeffrey M
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1083-3021
DOI
10.1007/s10911-005-2537-2
Published
2005-01-00
Pages
17-24
Language
English
Region
United States
NLM ID
9601804
Subset
IM
Grants
NCI NIH HHS · U01 CA84243-06 · United States
External Links
PubMed source DOI: 10.1007/s10911-005-2537-2 View journal details
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