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PMID: 18581050 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Diverse molecular functions of Hu proteins.

Cellular and molecular life sciences : CMLS ·Vol. 65 ·No. 20 ·2008-10-00 ·Pages 3168-81

Hinman MN, Lou H

Abstract

Hu proteins are RNA-binding proteins involved in diverse biological processes. The neuronal members of the Hu family, HuB, HuC, and HuD play important roles in neuronal differentiation and plasticity, while the ubiquitously expressed family member, HuR, has numerous functions mostly related to cellular stress response. The pivotal roles of Hu proteins are dictated by their molecular functions affecting a large number of target genes. Hu proteins affect many post-transcriptional aspects of RNA metabolism, from splicing to translation. In this communication, we will focus on these molecular events and review our current understanding of how Hu proteins mediate them. In particular, emphasis will be put on the nuclear functions of these proteins, which were recently discovered. Three examples including calcitonin/calcitonin gene-related peptide, neurofibromatosis type 1, and Ikaros will be discussed in detail. In addition, an intriguing theme of antagonism between Hu proteins and other AU-rich sequence binding proteins will be discussed.

MeSH Terms
Animals Brain/metabolism Calcitonin Gene-Related Peptide/metabolism Cell Nucleus/metabolism ELAV Proteins/metabolism Humans Protein Biosynthesis RNA Stability
Chemicals
ELAV Proteins Calcitonin Gene-Related Peptide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hinman M N
Department of Genetics, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, Ohio 44106, USA.
Lou H
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-682X
DOI
10.1007/s00018-008-8252-6
Published
2008-10-00
Pages
3168-81
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC2580827
Subset
IM
Grants
PHS HHS · NF060083 · United States
NINDS NIH HHS · R01 NS049103 · United States
NIGMS NIH HHS · T32GM008613 · United States
NINDS NIH HHS · NS-049103 · United States
NINDS NIH HHS · R01 NS049103-04 · United States
External Links
PubMed source DOI: 10.1007/s00018-008-8252-6 PMC Full Text View journal details
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