Home LiteratureArticle Details
PMID: 18663603 Published · ppublish English Guideline Journal Article

Guidelines for the nomenclature of the human heat shock proteins.

Cell stress & chaperones ·Vol. 14 ·No. 1 ·2009-01-00 ·Pages 105-11

Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE

Abstract

The expanding number of members in the various human heat shock protein (HSP) families and the inconsistencies in their nomenclature have often led to confusion. Here, we propose new guidelines for the nomenclature of the human HSP families, HSPH (HSP110), HSPC (HSP90), HSPA (HSP70), DNAJ (HSP40), and HSPB (small HSP) as well as for the human chaperonin families HSPD/E (HSP60/HSP10) and CCT (TRiC). The nomenclature is based largely on the more consistent nomenclature assigned by the HUGO Gene Nomenclature Committee and used in the National Center of Biotechnology Information Entrez Gene database for the heat shock genes. In addition to this nomenclature, we provide a list of the human Entrez Gene IDs and the corresponding Entrez Gene IDs for the mouse orthologs.

MeSH Terms
Animals Chaperonins/classification,genetics HSP110 Heat-Shock Proteins/classification HSP40 Heat-Shock Proteins/classification HSP70 Heat-Shock Proteins/classification HSP90 Heat-Shock Proteins/classification Heat-Shock Proteins/classification Heat-Shock Proteins, Small/classification Humans Mice Molecular Chaperones/classification,genetics Terminology as Topic
Chemicals
HSP110 Heat-Shock Proteins HSP40 Heat-Shock Proteins HSP70 Heat-Shock Proteins HSP90 Heat-Shock Proteins Heat-Shock Proteins Heat-Shock Proteins, Small Molecular Chaperones Chaperonins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Kampinga Harm H
Department of Cell Biology, Section of Radiation and Stress Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. [email protected]
Hageman Jurre
Vos Michel J
Kubota Hiroshi
Tanguay Robert M
Bruford Elspeth A
Cheetham Michael E
Chen Bin
Hightower Lawrence E
References (14)
14 references, click to expand
  1. Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s.
    EMBO J. 2006 Jun 7;25(11):2519-28 PMID: 16688212
  2. The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47).
    Gene. 1999 Feb 18;227(2):241-8 PMID: 10023073
  3. The HSP90 family of genes in the human genome: insights into their divergence and evolution.
    Genomics. 2005 Dec;86(6):627-37 PMID: 16269234
  4. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions.
    Protein Sci. 2005 Jul;14(7):1697-709 PMID: 15987899
  5. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature.
    Cell Stress Chaperones. 2000 Apr;5(2):98-112 PMID: 11147971
  6. Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms.
    BMC Genomics. 2006 Jun 17;7:156 PMID: 16780600
  7. A hitchhiker's guide to the human Hsp70 family.
    Cell Stress Chaperones. 1996 Apr;1(1):23-8 PMID: 9222585
  8. Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor.
    EMBO J. 2006 Jun 7;25(11):2510-8 PMID: 16688211
  9. The J-protein family: modulating protein assembly, disassembly and translocation.
    EMBO Rep. 2004 Jun;5(6):567-71 PMID: 15170475
  10. Cloning and sequence analysis of Hsp89alpha DeltaN, a new member of theHsp90 gene family.
    Biochim Biophys Acta. 1998 May 29;1398(1):18-24 PMID: 9602032
  11. hsp70 genes in the human genome: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions.
    BMC Evol Biol. 2008 Jan 23;8:19 PMID: 18215318
  12. Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome.
    Am J Hum Genet. 2007 Jan;80(1):1-11 PMID: 17160889
  13. Database resources of the National Center for Biotechnology Information.
    Nucleic Acids Res. 2008 Jan;36(Database issue):D13-21 PMID: 18045790
  14. BBS10 encodes a vertebrate-specific chaperonin-like protein and is a major BBS locus.
    Nat Genet. 2006 May;38(5):521-4 PMID: 16582908
Article Info
Journal
Cell stress & chaperones
Abbr.
Cell Stress Chaperones
ISSN
1355-8145
Published
2009-01-00
Epub
2008-00-29
Pages
105-11
Language
English
Region
Netherlands
NLM ID
9610925
PMCID
PMC2673902
Subset
IM
Grants
NHGRI NIH HHS · P41 HG003345 · United States
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]