Biological and electron microscopic studies on the phenotypic mixing of the thermolabile mutant of vesicular stomatitis virus, tl-17, with avian RNA tumor viruses.

Archives of virology ·Vol. 52 ·No. 3 ·1976-00-00 ·Pages 233-42

Ogura H, Bauer H

Abstract

A thermolabile as well as thermosensitive mutant of vesicular stomatitis virus, VSV-tl-17, could be thermostabilized by phenotypic mixing with avian RNA tumor viruses (ATV). Biological, immunological and morphological studies revealed that this effect is due to a replacement of the thermolabile projections of the VSV by the avian tumor viral projections. The arrangement of projections of VSV and ATV on phenotypically mixed viria was studied by electron microscopy. A-type particles were detected in chick embryo cells which were doubly infected by ATV and VSV. Their intracytoplasmic appearance seemed to be the result of a disturbed maturation of ATV due to the relative deficiency of envelope proteins which were depleted by VSV maturation in the course of phenotypic mixing.

MeSH Terms

Alpharetrovirus/immunology Animals Avian Leukosis Virus Avian Sarcoma Viruses Chick Embryo Culture Techniques Immune Sera Mutation Neutralization Tests Phenotype Quail Temperature Vesicular stomatitis Indiana virus/growth & development,immunology,ultrastructure Viral Proteins

Chemicals

Immune Sera Viral Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ogura H

Bauer H

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23 references, click to expand

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Article Info

Journal

Archives of virology

Abbr.

Arch Virol

ISSN

0304-8608

DOI

10.1007/BF01348020

Published

1976-00-00

Pages

233-42

Language

English

Region

Austria

NLM ID

7506870

Subset

External Links

PubMed source DOI: 10.1007/BF01348020 View journal details

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Biological and electron microscopic studies on the phenotypic mixing of the thermolabile mutant of vesicular stomatitis virus, tl-17, with avian RNA tumor viruses.

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