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PMID: 18772897 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Eating the enemy within: autophagy in infectious diseases.

Cell death and differentiation ·Vol. 16 ·No. 1 ·2009-01-00 ·Pages 57-69

Orvedahl A, Levine B

Abstract

Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.

MeSH Terms
Animals Autophagy/immunology Bacterial Infections/immunology,therapy Biological Evolution Host-Pathogen Interactions/immunology Humans Mycoses/immunology,therapy Parasitic Diseases/immunology,therapy Virus Diseases/immunology,therapy
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Orvedahl A
Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Levine B
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Article Info
Journal
Cell death and differentiation
Abbr.
Cell Death Differ
ISSN
1476-5403
DOI
10.1038/cdd.2008.130
Published
2009-01-00
Epub
2008-00-05
Pages
57-69
Language
English
Region
England
NLM ID
9437445
PMCID
PMC2736877
Subset
IM
Grants
PHS HHS · R01 A10151367 · United States
PHS HHS · T32 A1007520 · United States
NIAID NIH HHS · R01 AI051367 · United States
Howard Hughes Medical Institute · United States
NIAID NIH HHS · R01 AI051367-06 · United States
External Links
PubMed source DOI: 10.1038/cdd.2008.130 PMC Full Text View journal details
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