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PMID: 18604211 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Autophagic control of listeria through intracellular innate immune recognition in drosophila.

Nature immunology ·Vol. 9 ·No. 8 ·2008-08-00 ·Pages 908-16

Yano T, Mita S, Ohmori H, Oshima Y, Fujimoto Y, Ueda R, Takada H, Goldman WE, Fukase K, Silverman N, Yoshimori T, Kurata S

Abstract

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.

MeSH Terms
Animals Autophagy Diaminopimelic Acid Drosophila/genetics,growth & development,immunology,metabolism Immunity, Innate/immunology Listeria/cytology,immunology Peptidoglycan/immunology,metabolism Toll-Like Receptors/immunology
Chemicals
Peptidoglycan Toll-Like Receptors Diaminopimelic Acid
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Yano Tamaki
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan.
Mita Shizuka
Ohmori Hiroko
Oshima Yoshiteru
Fujimoto Yukari
Ueda Ryu
Takada Haruhiko
Goldman William E
Fukase Koichi
Silverman Neal
Yoshimori Tamotsu
Kurata Shoichiro
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.1634
Published
2008-08-00
Epub
2008-00-06
Pages
908-16
Language
English
Region
United States
NLM ID
100941354
PMCID
PMC2562576
Subset
IM
Grants
NIAID NIH HHS · R01 AI074958 · United States
NIAID NIH HHS · AI60025 · United States
NIAID NIH HHS · R01 AI074958-01A1 · United States
NIAID NIH HHS · R56 AI060025 · United States
NIAID NIH HHS · AI074958 · United States
NIAID NIH HHS · R01 AI060025 · United States
NIAID NIH HHS · R01 AI060025-04 · United States
NIAID NIH HHS · R01 AI060025-05 · United States
Corrections
CommentIn
PMID: 18645586
External Links
PubMed source DOI: 10.1038/ni.1634 PMC Full Text View journal details
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