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PMID: 9405661 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 26 ·1997-12-23 ·Pages 14614-9

Lemaitre B, Reichhart JM, Hoffmann JA

Abstract

Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various classes of microorganisms. We first observe that the genes encoding antibacterial and antifungal peptides are differentially expressed after injection of distinct microorganisms. More strikingly, Drosophila that are naturally infected by entomopathogenic fungi exhibit an adapted response by producing only peptides with antifungal activities. This response is mediated through the selective activation of the Toll pathway.

MeSH Terms
Animals Drosophila/immunology,microbiology Genes, Insect Immunity/genetics Peptides/genetics,immunology
Chemicals
Peptides
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lemaitre B
Institut de Biologie Moléculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, 15 rue René Descartes, 67084 Strasbourg Cedex, France.
Reichhart J M
Hoffmann J A
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.26.14614
Published
1997-12-23
Pages
14614-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC25070
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.26.14614 PMC Full Text View journal details
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