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PMID: 188579 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy.

Clinical and experimental immunology ·Vol. 26 ·No. 3 ·1976-12-00 ·Pages 478-83

Schauf V, Strelkauskas AJ, Deveikis A

Abstract

The distribution of immunoglobulin bearing (Ig+), T, and null lymphocyte subpopulations and the lymphocyte response to phytohaemagglutinin (PHA) and pokeweed mitogen (PWM) were determined in three infants with cytomegalovirus (CMV) infection. These infants had significantly decreased percentages of T cells (13%, 29% and 40%) compared to age-matched controls (61 +/- 2%). Compensatory increases in the percentages of Ig+ and null cells occurred. Decreased lymphocyte reactivity to PHA and PWM occurred in two patients. Purified T cells from these patients had normal reactivity indicating a disproportion of T cells in the peripheral blood. These abnormalities may result from CMV infection of lymphocytes and could be responsible for prolonged CMV viruria.

MeSH Terms

Cytomegalovirus Infections/immunology Female Humans Immunity, Cellular Immunoglobulins/analysis Infant Infant, Newborn Leukocyte Count Lymphocyte Activation Lymphocytes/immunology Male T-Lymphocytes

Chemicals

Immunoglobulins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Schauf V

Strelkauskas A J

Deveikis A

References (15)

15 references, click to expand

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Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1976-12-00

Pages

478-83

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1540970

Subset

External Links

PubMed source PMC Full Text View journal details

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Alteration of lymphocyte subpopulations with cytomegalovirus infection in infancy.

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