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PMID: 19004190 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Biomarkers related to aging in human populations.

Advances in clinical chemistry ·Vol. 46 ·2008-00-00 ·Pages 161-216

Crimmins E, Vasunilashorn S, Kim JK, Alley D

Abstract

Biomarkers are increasingly employed in empirical studies of human populations to understand physiological processes that change with age, diseases whose onset appears linked to age, and the aging process itself. In this chapter, we describe some of the most commonly used biomarkers in population aging research, including their collection, associations with other markers, and relationships to health outcomes. We discuss biomarkers of the cardiovascular system, metabolic processes, inflammation, activity in the hypothalamic-pituitary axis (HPA) and sympathetic nervous system (SNS), and organ functioning (including kidney, lung, and heart). In addition, we note that markers of functioning of the central nervous system and genetic markers are now becoming part of population measurement. Where possible, we detail interrelationships between these markers by providing correlations between high risk levels of each marker from three population-based surveys: the National Health and Nutrition Examination Survey (NHANES) III, NHANES 1999-2002, and the MacArthur Study of Successful Aging. NHANES III is used instead of NHANES 1999-2002 when specific markers of interest are available only in NHANES III and when we examine the relationship of biomarkers to mortality which is only known for NHANES III. We also describe summary measures combining biomarkers across systems. Finally, we examine associations between individual markers and mortality and provide information about biomarkers of growing interest for future research in population aging and health.

MeSH Terms
Aging/genetics,physiology Biomarkers Body Mass Index C-Reactive Protein/analysis Cardiovascular Physiological Phenomena Catecholamines/urine Genetic Markers Humans Interleukin-6/blood Lipids/blood
Chemicals
Biomarkers Catecholamines Genetic Markers Interleukin-6 Lipids C-Reactive Protein
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Crimmins Eileen
Andrus Gerontology Center, Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Vasunilashorn Sarinnapha
Kim Jung Ki
Alley Dawn
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Article Info
Journal
Advances in clinical chemistry
Abbr.
Adv Clin Chem
ISSN
0065-2423
DOI
10.1016/s0065-2423(08)00405-8
Published
2008-00-00
Pages
161-216
Language
English
Region
United States
NLM ID
2985173R
PMCID
PMC5938178
Subset
IM
Grants
NIA NIH HHS · P30 AG017265 · United States
NIA NIH HHS · T32 AG000037 · United States
NIA NIH HHS · P30 AG17265 · United States
External Links
PubMed source DOI: 10.1016/s0065-2423(08)00405-8 PMC Full Text View journal details
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