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PMID: 19021755 Published · ppublish English Lecture Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A decade of Cdc14--a personal perspective. Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria.

The FEBS journal ·Vol. 275 ·No. 23 ·2008-12-00 ·Pages 5774-84

Amon A

Abstract

In budding yeast, the protein phosphatase Cdc14 is a key regulator of late mitotic events. Research over the last decade has revealed many of its functions and today we know that this protein phosphatase orchestrates several aspects of chromosome segregation and is the key trigger of exit from mitosis. Elucidation of the mechanisms controlling Cdc14 activity through nucleolar sequestration now serves as a paradigm for how regulation of the subcellular localization of proteins regulates protein function. Here I review these findings focusing on how discoveries in my laboratory helped elucidate the function and regulation of Cdc14.

MeSH Terms
Anaphase/physiology Cell Cycle Proteins/metabolism Cell Nucleolus/metabolism,physiology Chromosome Segregation/physiology Cyclin B/metabolism Cyclin-Dependent Kinases/metabolism Metaphase/physiology Mitosis/physiology Models, Biological Protein Tyrosine Phosphatases/metabolism Saccharomyces cerevisiae Proteins/metabolism
Chemicals
CDC14 protein, S cerevisiae CLB2 protein, S cerevisiae Cell Cycle Proteins Cyclin B Saccharomyces cerevisiae Proteins Cyclin-Dependent Kinases Protein Tyrosine Phosphatases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Amon Angelika
David H. Koch Institute for Integrative Cancer Research, Cambridge, MA, USA. [email protected]
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Article Info
Journal
The FEBS journal
Abbr.
FEBS J
ISSN
1742-4658
DOI
10.1111/j.1742-4658.2008.06693.x
Email
[email protected]
Published
2008-12-00
Pages
5774-84
Language
English
Region
England
NLM ID
101229646
PMCID
PMC2742780
Subset
IM
Grants
NIGMS NIH HHS · R01 GM056800-13 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R29 GM056800 · United States
NIGMS NIH HHS · R01 GM056800 · United States
NIGMS NIH HHS · GM056800 · United States
NIGMS NIH HHS · R29 GM056800-04 · United States
External Links
PubMed source DOI: 10.1111/j.1742-4658.2008.06693.x PMC Full Text View journal details
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