Home LiteratureArticle Details
PMID: 19118207 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Integrin signalling at a glance.

Journal of cell science ·Vol. 122 ·No. Pt 2 ·2009-01-15 ·Pages 159-63

Harburger DS, Calderwood DA

Abstract

暂无摘要

MeSH Terms
Animals Cell Adhesion/physiology Cell Communication/physiology Extracellular Matrix/physiology Humans Integrins/metabolism Paxillin/metabolism Protein Kinases/metabolism Signal Transduction Talin/metabolism Vinculin/metabolism
Chemicals
Integrins Paxillin Talin Vinculin Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Harburger David S
Department of Pharmacology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT 06520, USA.
Calderwood David A
References (56)
56 references, click to expand
  1. ILK, PINCH and parvin: the tIPP of integrin signalling.
    Nat Rev Mol Cell Biol. 2006 Jan;7(1):20-31 PMID: 16493410
  2. Kindlin-3 is essential for integrin activation and platelet aggregation.
    Nat Med. 2008 Mar;14(3):325-30 PMID: 18278053
  3. The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin.
    Nat Struct Biol. 2002 Feb;9(2):101-6 PMID: 11799401
  4. Three-dimensional microenvironments modulate fibroblast signaling responses.
    Adv Drug Deliv Rev. 2007 Nov 10;59(13):1293-8 PMID: 17825946
  5. Differential transmission of actin motion within focal adhesions.
    Science. 2007 Jan 5;315(5808):111-5 PMID: 17204653
  6. A molecular switch that controls cell spreading and retraction.
    J Cell Biol. 2007 Nov 5;179(3):553-65 PMID: 17967945
  7. Calpain-mediated proteolysis of talin regulates adhesion dynamics.
    Nat Cell Biol. 2004 Oct;6(10):977-83 PMID: 15448700
  8. Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.
    Structure. 2003 Oct;11(10):1207-17 PMID: 14527389
  9. Focal adhesion kinase: in command and control of cell motility.
    Nat Rev Mol Cell Biol. 2005 Jan;6(1):56-68 PMID: 15688067
  10. The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.
    J Biol Chem. 2008 Mar 7;283(10):6118-25 PMID: 18165225
  11. The integrin-growth factor receptor duet.
    J Cell Physiol. 2007 Dec;213(3):649-53 PMID: 17886260
  12. Integrin activation.
    J Cell Sci. 2004 Feb 15;117(Pt 5):657-66 PMID: 14754902
  13. Integrin cytoplasmic domain-binding proteins.
    J Cell Sci. 2000 Oct;113 ( Pt 20):3563-71 PMID: 11017872
  14. Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling.
    J Cell Sci. 2008 May 15;121(Pt 10):1641-8 PMID: 18430780
  15. Talin at a glance.
    J Cell Sci. 2008 May 1;121(Pt 9):1345-7 PMID: 18434644
  16. An interaction between integrin and the talin FERM domain mediates integrin activation but not linkage to the cytoskeleton.
    Nat Cell Biol. 2006 Jun;8(6):601-6 PMID: 16648844
  17. Kindlin-2 (Mig-2): a co-activator of beta3 integrins.
    J Cell Biol. 2008 May 5;181(3):439-46 PMID: 18458155
  18. Endocytic transport of integrins during cell migration and invasion.
    Trends Cell Biol. 2008 Jun;18(6):257-63 PMID: 18456497
  19. Complexes of tetraspanins with integrins: more than meets the eye.
    J Cell Sci. 2001 Dec;114(Pt 23):4143-51 PMID: 11739647
  20. Substrate rigidity and force define form through tyrosine phosphatase and kinase pathways.
    Trends Cell Biol. 2006 Apr;16(4):213-23 PMID: 16529933
  21. Integrin-linked kinase: a cancer therapeutic target unique among its ILK.
    Nat Rev Cancer. 2005 Jan;5(1):51-63 PMID: 15630415
  22. Integrin ligands at a glance.
    J Cell Sci. 2006 Oct 1;119(Pt 19):3901-3 PMID: 16988024
  23. Structural basis for the autoinhibition of focal adhesion kinase.
    Cell. 2007 Jun 15;129(6):1177-87 PMID: 17574028
  24. Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.
    Blood. 2008 Sep 1;112(5):1853-62 PMID: 18550856
  25. Structural basis for the autoinhibition of talin in regulating integrin activation.
    Mol Cell. 2008 Jul 11;31(1):124-33 PMID: 18614051
  26. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3.
    J Cell Biol. 2008 Jun 30;181(7):1211-22 PMID: 18573917
  27. The molecular basis of filamin binding to integrins and competition with talin.
    Mol Cell. 2006 Feb 3;21(3):337-47 PMID: 16455489
  28. Structural determinants of integrin recognition by talin.
    Mol Cell. 2003 Jan;11(1):49-58 PMID: 12535520
  29. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.
    Curr Biol. 2006 Sep 19;16(18):1796-806 PMID: 16979556
  30. Integrins: bidirectional, allosteric signaling machines.
    Cell. 2002 Sep 20;110(6):673-87 PMID: 12297042
  31. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
    J Exp Med. 2007 Dec 24;204(13):3113-8 PMID: 18086864
  32. Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinity.
    J Cell Biol. 2008 Jan 28;180(2):427-41 PMID: 18227284
  33. Paxillin comes of age.
    J Cell Sci. 2008 Aug 1;121(Pt 15):2435-44 PMID: 18650496
  34. Kindlin-2 controls bidirectional signaling of integrins.
    Genes Dev. 2008 May 15;22(10):1325-30 PMID: 18483218
  35. Integrin regulation.
    Curr Opin Cell Biol. 2005 Oct;17(5):509-16 PMID: 16099636
  36. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion.
    J Biol Chem. 2004 Feb 20;279(8):6824-33 PMID: 14634021
  37. Functional atlas of the integrin adhesome.
    Nat Cell Biol. 2007 Aug;9(8):858-67 PMID: 17671451
  38. Talin binding to integrin beta tails: a final common step in integrin activation.
    Science. 2003 Oct 3;302(5642):103-6 PMID: 14526080
  39. Synergistic control of cell adhesion by integrins and syndecans.
    Nat Rev Mol Cell Biol. 2007 Dec;8(12):957-69 PMID: 17971838
  40. Forces and bond dynamics in cell adhesion.
    Science. 2007 May 25;316(5828):1148-53 PMID: 17525329
  41. New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation.
    Biochem Pharmacol. 2006 Nov 30;72(11):1460-8 PMID: 16870156
  42. Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.
    Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2272-7 PMID: 12606711
  43. Structure of the integrin alphaIIb transmembrane segment.
    J Biol Chem. 2008 Jun 6;283(23):16162-8 PMID: 18417472
  44. Sensing the environment: a historical perspective on integrin signal transduction.
    Nat Cell Biol. 2002 Apr;4(4):E83-90 PMID: 11944041
  45. C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes.
    Curr Biol. 2002 May 14;12(10):787-97 PMID: 12015115
  46. Probing the integrin-actin linkage using high-resolution protein velocity mapping.
    J Cell Sci. 2006 Dec 15;119(Pt 24):5204-14 PMID: 17158922
  47. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling.
    J Biol Chem. 2000 Jul 28;275(30):22607-10 PMID: 10801899
  48. The structure and regulation of vinculin.
    Trends Cell Biol. 2006 Sep;16(9):453-60 PMID: 16893648
  49. Structural basis of integrin regulation and signaling.
    Annu Rev Immunol. 2007;25:619-47 PMID: 17201681
  50. Differences in regulation of Drosophila and vertebrate integrin affinity by talin.
    Mol Biol Cell. 2008 Aug;19(8):3589-98 PMID: 18508915
  51. Structural basis of integrin activation by talin.
    Cell. 2007 Jan 12;128(1):171-82 PMID: 17218263
  52. An integrin phosphorylation switch: the effect of beta3 integrin tail phosphorylation on Dok1 and talin binding.
    J Biol Chem. 2008 Feb 29;283(9):5420-6 PMID: 18156175
  53. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.
    J Clin Invest. 2007 Aug;117(8):2250-9 PMID: 17627302
  54. A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion.
    Blood. 2008 Dec 1;112(12):4523-31 PMID: 18772455
  55. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles.
    Biochemistry. 2008 Apr 1;47(13):4008-16 PMID: 18321071
  56. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain.
    Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13298-302 PMID: 14593208
Article Info
Journal
Journal of cell science
Abbr.
J Cell Sci
ISSN
0021-9533
Published
2009-01-15
Pages
159-63
Language
English
Region
England
NLM ID
0052457
PMCID
PMC2714413
Subset
IM
Grants
NIGMS NIH HHS · R01 GM068600 · United States
NHLBI NIH HHS · R21 HL089433 · United States
Corrections
ErratumIn
-
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]