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PMID: 19223160 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review

Sensing pathogens and danger signals by the inflammasome.

Current opinion in immunology ·Vol. 21 ·No. 1 ·2009-02-00 ·Pages 10-6

Pedra JH, Cassel SL, Sutterwala FS

Abstract

The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wide range of stimuli including both microbial and self-molecules. Caspase-1 activation leads to processing and secretion of the proinflammatory cytokines interleukin-1beta (IL-1beta) and IL-18, which play crucial roles in host defense to infectious insults. Dysregulation of the inflammasome has also been linked to a number of autoinflammatory and autoimmune disorders. Recent advances in the inflammasome field will be discussed in this review.

MeSH Terms
Adaptor Proteins, Signal Transducing/genetics,immunology Animals Apoptosis Regulatory Proteins/genetics,immunology Autoimmune Diseases/genetics Bacterial Infections/genetics,immunology CARD Signaling Adaptor Proteins/genetics,immunology Calcium-Binding Proteins/genetics,immunology Caspase 1/genetics,immunology Gene Expression Regulation Genetic Predisposition to Disease Host-Pathogen Interactions Humans Immunity, Innate Intercellular Signaling Peptides and Proteins/genetics,immunology Interleukin-1beta/immunology NLR Proteins Polymorphism, Genetic Signal Transduction
Chemicals
Adaptor Proteins, Signal Transducing Apoptosis Regulatory Proteins CARD Signaling Adaptor Proteins Calcium-Binding Proteins Intercellular Signaling Peptides and Proteins Interleukin-1beta NLR Proteins NLRC3 protein, human NLRC4 protein, human NLRP1 protein, human Caspase 1
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pedra Joao H F
Institute for Integrative Genome Biology and Department of Entomology, University of California-Riverside, 92521, USA. [email protected]
Cassel Suzanne L
Sutterwala Fayyaz S
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
1879-0372
DOI
10.1016/j.coi.2009.01.006
Email
[email protected]
Published
2009-02-00
Epub
2009-00-14
Pages
10-6
Language
English
Region
England
NLM ID
8900118
PMCID
PMC2701640
Subset
IM
Grants
NCEZID CDC HHS · K01 CK000101 · United States
NIAID NIH HHS · K08 AI065517 · United States
NIAID NIH HHS · K08 AI065517-04 · United States
NIAID NIH HHS · K08 AI067736 · United States
Corrections
CommentIn
PMID: 19223161
External Links
PubMed source DOI: 10.1016/j.coi.2009.01.006 PMC Full Text View journal details
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