Home LiteratureArticle Details
PMID: 1924384 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 20 ·1991-10-15 ·Pages 9214-8

Wharton KA, Thomsen GH, Gelbart WM

Abstract

The 60A gene, a member of the transforming growth factor beta superfamily of signaling proteins, has been identified in Drosophila melanogaster. From its inferred protein sequence we predict the precursor is secreted and processed to release a growth factor-like molecule. The 60A gene is expressed throughout development with peaks of transcription during early embryogenesis, in pupae, and in adult males. The putative 60A protein shows greater sequence similarity to three vertebrate family members (human bone morphogenetic proteins 5, 6, and 7) than to its only Drosophila relative, the protein product of the decapentaplegic (dpp) gene. This observation suggests that the duplication event that gave rise to the two transforming growth factor beta-like proteins in Drosophila predates the divergence of chordates and arthropods.

Related Genes
60A dpp
MeSH Terms
Amino Acid Sequence Animals Base Sequence Bone Morphogenetic Proteins DNA/genetics Drosophila/embryology,genetics,growth & development Genomic Library Humans Molecular Sequence Data Multigene Family Oligonucleotides Phylogeny Polymerase Chain Reaction Proteins/genetics Restriction Mapping Sequence Homology, Nucleic Acid Transforming Growth Factor beta/genetics
Chemicals
Bone Morphogenetic Proteins Oligonucleotides Proteins Transforming Growth Factor beta DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wharton K A
Department of Cellular, Harvard University, Cambridge, MA 02138.
Thomsen G H
Gelbart W M
References (42)
42 references, click to expand
  1. Transforming growth factor production by chemically transformed cells.
    Cancer Res. 1981 Jul;41(7):2842-8 PMID: 6265069
  2. Functional cDNA libraries from Drosophila embryos.
    J Mol Biol. 1988 Sep 20;203(2):425-37 PMID: 3199441
  3. Decapentaplegic: a gene complex affecting morphogenesis in Drosophila melanogaster.
    Cell. 1982 Mar;28(3):451-61 PMID: 6804094
  4. A comprehensive set of sequence analysis programs for the VAX.
    Nucleic Acids Res. 1984 Jan 11;12(1 Pt 1):387-95 PMID: 6546423
  5. Sequence, structure, and codon preference of the Drosophila ribosomal protein 49 gene.
    Nucleic Acids Res. 1984 Jul 11;12(13):5495-513 PMID: 6087289
  6. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.
    Plasmid. 1985 Jan;13(1):31-40 PMID: 3991809
  7. Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.
    Nature. 1985 Aug 22-28;316(6030):701-5 PMID: 3861940
  8. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta.
    Nature. 1985 Dec 19-1986 Jan 1;318(6047):659-63 PMID: 2417121
  9. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid.
    Nature. 1986 Jun 19-25;321(6072):776-9 PMID: 3012369
  10. Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin.
    Nature. 1986 Jun 19-25;321(6072):779-82 PMID: 3086749
  11. Transforming growth factor-beta: biological function and chemical structure.
    Science. 1986 Aug 1;233(4763):532-4 PMID: 3487831
  12. A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-beta family.
    Nature. 1987 Jan 1-7;325(6099):81-4 PMID: 3467201
  13. Intron-exon structure of the human transforming growth factor-beta precursor gene.
    Nucleic Acids Res. 1987 Apr 10;15(7):3188-9 PMID: 3470709
  14. Novel regulators of bone formation: molecular clones and activities.
    Science. 1988 Dec 16;242(4885):1528-34 PMID: 3201241
  15. A new type of transforming growth factor-beta, TGF-beta 3.
    EMBO J. 1988 Dec 1;7(12):3737-43 PMID: 3208746
  16. Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming growth factor beta 4 from chicken embryo chondrocytes.
    Mol Endocrinol. 1988 Dec;2(12):1186-95 PMID: 2464131
  17. Transforming growth factor beta.
    Adv Cancer Res. 1988;51:107-45 PMID: 2906217
  18. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4554-8 PMID: 2734307
  19. Transforming growth factor beta 1: importance of glycosylation and acidic proteases for processing and secretion.
    Mol Endocrinol. 1989 Jul;3(7):1090-8 PMID: 2677679
  20. Mesoderm induction and mesoderm-inducing factors in early amphibian development.
    Development. 1989 Apr;105(4):665-77 PMID: 2689132
  21. Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.
    Genes Dev. 1989 Nov;3(11):1657-68 PMID: 2481605
  22. Identification of a novel transforming growth factor-beta (TGF-beta 5) mRNA in Xenopus laevis.
    J Biol Chem. 1990 Jan 15;265(2):1089-93 PMID: 2295601
  23. Biochemical characterization of the Drosophila dpp protein, a member of the transforming growth factor beta family of growth factors.
    Mol Cell Biol. 1990 Jun;10(6):2669-77 PMID: 1692958
  24. TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.
    Cell. 1990 Jun 15;61(6):1051-61 PMID: 2350783
  25. OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.
    EMBO J. 1990 Jul;9(7):2085-93 PMID: 2357959
  26. Induction across germ layers in Drosophila mediated by a genetic cascade.
    Cell. 1990 Jul 27;62(2):261-8 PMID: 1973634
  27. The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor.
    Biochemistry. 1990 Jul 24;29(29):6851-7 PMID: 2397217
  28. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures.
    Cell. 1990 Nov 2;63(3):485-93 PMID: 2225062
  29. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.
    Proc Natl Acad Sci U S A. 1990 Dec;87(24):9843-7 PMID: 2263636
  30. The transforming growth factor-beta family.
    Annu Rev Cell Biol. 1990;6:597-641 PMID: 2177343
  31. Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily.
    Mol Endocrinol. 1990 Jul;4(7):1034-40 PMID: 1704486
  32. Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary.
    Mech Dev. 1990 Dec;33(1):69-82 PMID: 2129012
  33. A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis.
    Development. 1990 Dec;110(4):1041-50 PMID: 1983114
  34. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.
    Cell. 1987 Dec 4;51(5):861-7 PMID: 3479264
  35. Decapentaplegic transcripts are localized along the dorsal-ventral axis of the Drosophila embryo.
    EMBO J. 1987 Sep;6(9):2785-91 PMID: 3119329
  36. Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-beta gene family.
    EMBO J. 1987 Dec 1;6(12):3673-7 PMID: 3322813
  37. The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo.
    Genes Dev. 1987 Oct;1(8):868-79 PMID: 3123323
  38. Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
    Science. 1988 Feb 12;239(4841 Pt 1):783-5 PMID: 3422517
  39. Transforming growth factor-beta 2: cDNA cloning and sequence analysis.
    DNA. 1988 Jan-Feb;7(1):1-8 PMID: 3162414
  40. Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.
    J Biol Chem. 1988 Jun 5;263(16):7646-54 PMID: 3163692
  41. Identification of another member of the transforming growth factor type beta gene family.
    Proc Natl Acad Sci U S A. 1988 Jul;85(13):4715-9 PMID: 3164476
  42. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.
    Proc Natl Acad Sci U S A. 1981 Sep;78(9):5339-43 PMID: 6975480
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.20.9214
Published
1991-10-15
Pages
9214-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52684
Subset
IM
Databases
GENBANK
M67441, M77012, S60069, S60071, S60073, S60076, S60079, S60081, S60988, S61031
External Links
PubMed source DOI: 10.1073/pnas.88.20.9214 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2