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PMID: 19277046 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

The emerging role of nuclear architecture in DNA repair and genome maintenance.

Nature reviews. Molecular cell biology ·Vol. 10 ·No. 4 ·2009-04-00 ·Pages 243-54

Misteli T, Soutoglou E

Abstract

DNA repair and maintenance of genome stability are crucial to cellular and organismal function, and defects in these processes have been implicated in cancer and ageing. Detailed molecular, biochemical and genetic analyses have outlined the molecular framework involved in cellular DNA-repair pathways, but recent cell-biological approaches have revealed important roles for the spatial and temporal organization of the DNA-repair machinery during the recognition of DNA lesions and the assembly of repair complexes. It has also become clear that local higher-order chromatin structure, chromatin dynamics and non-random global genome organization are key factors in genome maintenance. These cell-biological features of DNA repair illustrate an emerging role for nuclear architecture in multiple aspects of genome maintenance.

MeSH Terms
Animals Cell Nucleus/genetics Chromatin/metabolism DNA Damage DNA Repair Genome Humans Models, Biological
Chemicals
Chromatin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Misteli Tom
National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. [email protected]
Soutoglou Evi
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm2651
Email
[email protected]
Published
2009-04-00
Epub
2009-00-11
Pages
243-54
Language
English
Region
England
NLM ID
100962782
PMCID
PMC3478884
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010309-09 · United States
External Links
PubMed source DOI: 10.1038/nrm2651 PMC Full Text View journal details
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