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PMID: 19299327 Published · ppublish English Historical Article Journal Article Portrait Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The LDL receptor.

Arteriosclerosis, thrombosis, and vascular biology ·Vol. 29 ·No. 4 ·2009-04-00 ·Pages 431-8

Goldstein JL, Brown MS

Abstract

In this article, the history of the LDL receptor is recounted by its codiscoverers. Their early work on the LDL receptor explained a genetic cause of heart attacks and led to new ways of thinking about cholesterol metabolism. The LDL receptor discovery also introduced three general concepts to cell biology: receptor-mediated endocytosis, receptor recycling, and feedback regulation of receptors. The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life.

MeSH Terms
Animals Cholesterol/blood,history,metabolism Endocytosis Feedback, Physiological History, 20th Century History, 21st Century Humans Hydroxymethylglutaryl CoA Reductases/metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use Lipoproteins, LDL/blood,history,metabolism Myocardial Infarction/genetics,history,metabolism,prevention & control Protein Transport Receptors, LDL/genetics,history,metabolism Signal Transduction/genetics
Chemicals
Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipoproteins, LDL Receptors, LDL Cholesterol Hydroxymethylglutaryl CoA Reductases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goldstein Joseph L
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390-9046, USA. [email protected]
Brown Michael S
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Article Info
Journal
Arteriosclerosis, thrombosis, and vascular biology
Abbr.
Arterioscler Thromb Vasc Biol
ISSN
1524-4636
DOI
10.1161/ATVBAHA.108.179564
Email
[email protected]
Published
2009-04-00
Pages
431-8
Language
English
Region
United States
NLM ID
9505803
PMCID
PMC2740366
Subset
IM
Grants
NHLBI NIH HHS · P01 HL020948 · United States
NHLBI NIH HHS · P01 HL020948-32 · United States
NHLBI NIH HHS · HL20948 · United States
External Links
PubMed source DOI: 10.1161/ATVBAHA.108.179564 PMC Full Text View journal details
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