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PMID: 19308325 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The multifaceted role of periostin in tumorigenesis.

Cellular and molecular life sciences : CMLS ·Vol. 66 ·No. 14 ·2009-07-00 ·Pages 2219-30

Ruan K, Bao S, Ouyang G

Abstract

Periostin, also called osteoblast-specific factor 2 (OSF-2), is a member of the fasciclin family and a disulfide-linked cell adhesion protein that has been shown to be expressed preferentially in the periosteum and periodontal ligaments, where it acts as a critical regulator of bone and tooth formation and maintenance. Furthermore, periostin plays an important role in cardiac development. Recent clinical evidence has also revealed that periostin is involved in the development of various tumors, such as breast, lung, colon, pancreatic, and ovarian cancers. Periostin interacts with multiple cell-surface receptors, most notably integrins, and signals mainly via the PI3-K/Akt and other pathways to promote cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, aspects related to the function of periostin in tumorigenesis are summarized.

MeSH Terms
Cell Adhesion Molecules/genetics,metabolism,physiology Cell Proliferation Cell Survival Humans Neoplasm Invasiveness/genetics Neoplasm Metastasis/genetics Neoplasms/classification,genetics,metabolism
Chemicals
Cell Adhesion Molecules POSTN protein, human
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ruan Kai
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, China.
Bao Shideng
Ouyang Gaoliang
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-009-0013-7
Published
2009-07-00
Epub
2009-00-24
Pages
2219-30
Language
English
Region
Switzerland
NLM ID
9705402
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-009-0013-7 View journal details
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