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PMID: 19376575 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Phosphoinositide regulation of non-canonical transient receptor potential channels.

Cell calcium ·Vol. 45 ·No. 6 ·2009-06-00 ·Pages 554-65

Rohacs T

Abstract

Transient receptor potential (TRP) channels are involved in a wide range of physiological processes, and characterized by diverse activation mechanisms. Phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate [PIP(2), or PtdIns(4,5)P(2)] recently emerged as regulators of many TRP channels. Several TRP channels require PIP(2) for activity, and depletion of the lipid inhibits them. For some TRP channels, however, phosphoinositide regulation seems more complex, both activating and inhibitory effects have been reported. This review will discuss phosphoinositide regulation of members of the TRPM (Melastatin), TRPV (Vanilloid), TRPA (Ankyrin) and TRPP (Polycystin) families. Lipid regulation of TRPC (Canonical) channels is discussed elsewhere in this volume.

MeSH Terms
Calcium/metabolism Phosphatidylinositol 4,5-Diphosphate/metabolism Phosphatidylinositols/metabolism TRPC Cation Channels/metabolism TRPM Cation Channels/metabolism TRPP Cation Channels/metabolism TRPV Cation Channels/metabolism Transient Receptor Potential Channels/metabolism
Chemicals
Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositols TRPC Cation Channels TRPM Cation Channels TRPP Cation Channels TRPV Cation Channels Transient Receptor Potential Channels Calcium
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Rohacs Tibor
UMDNJ - New Jersey Medical School, Newark, NJ, USA. [email protected]
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Article Info
Journal
Cell calcium
Abbr.
Cell Calcium
ISSN
1532-1991
DOI
10.1016/j.ceca.2009.03.011
Email
[email protected]
Published
2009-06-00
Epub
2009-00-18
Pages
554-65
Language
English
Region
Netherlands
NLM ID
8006226
PMCID
PMC2720793
Subset
IM
Grants
NINDS NIH HHS · R01 NS055159 · United States
NINDS NIH HHS · R01 NS055159-02 · United States
NINDS NIH HHS · NS055159 · United States
External Links
PubMed source DOI: 10.1016/j.ceca.2009.03.011 PMC Full Text View journal details
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