In vitro binding of Helicobacter pylori to human gastric mucin.

Infection and immunity ·Vol. 59 ·No. 11 ·1991-11-00 ·Pages 4252-4

Tzouvelekis LS, Mentis AF, Makris AM, Spiliadis C, Blackwell C, Weir DM

Abstract

The in vitro binding of four Helicobacter pylori strains to human gastric mucin was studied with an enzyme-linked immunosorbent assay. All four strains were found to bind to purified mucin. Neuraminidase treatment and nonspecific oxidation of mucin decreased bacterial adherence to the macromolecule. Mucin preparations were also found to inhibit attachment of H. pylori to HEp-2 monolayers.

MeSH Terms

Bacterial Adhesion Gastric Mucosa/microbiology Helicobacter pylori/metabolism,pathogenicity Humans In Vitro Techniques Mucins/chemistry,metabolism

Chemicals

Mucins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Tzouvelekis L S

Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.

Mentis A F

Makris A M

Spiliadis C

Blackwell C

Weir D M

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16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.59.11.4252-4254.1991

Published

1991-11-00

Pages

4252-4

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC259024

Subset

External Links

PubMed source DOI: 10.1128/iai.59.11.4252-4254.1991 PMC Full Text View journal details

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In vitro binding of Helicobacter pylori to human gastric mucin.

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