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PMID: 19383377 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Large-scale genomic analysis of ovarian carcinomas.

Molecular oncology ·Vol. 3 ·No. 2 ·2009-04-00 ·Pages 157-64

Gorringe KL, Campbell IG

Abstract

Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high-resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro-deletions and amplifications. Many of these alterations contain cancer-related genes suggesting that the majority is disease-associated and not just the product of random genomic instability. Future developments such as next-generation sequencing and integrated analysis of data from multiple array platforms on large numbers of samples are poised to revolutionize our understanding of this complex disease.

MeSH Terms
Female Genome, Human Genomics Humans Mutation Ovarian Neoplasms/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gorringe Kylie L
VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
Campbell Ian G
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Article Info
Journal
Molecular oncology
Abbr.
Mol Oncol
ISSN
1878-0261
DOI
10.1016/j.molonc.2008.12.005
Published
2009-04-00
Epub
2008-00-24
Pages
157-64
Language
English
Region
United States
NLM ID
101308230
PMCID
PMC5527877
Subset
IM
External Links
PubMed source DOI: 10.1016/j.molonc.2008.12.005 PMC Full Text View journal details
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