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PMID: 19390624 Published · ppublish English Journal Article

Genetic variance in the adiponutrin gene family and childhood obesity.

PloS one ·Vol. 4 ·No. 4 ·2009-00-00 ·Pages e5327

Johansson LE, Johansson LM, Danielsson P, Norgren S, Johansson S, Marcus C, Ridderstråle M

Abstract

The adiponutrin gene family consists of five genes (PNPLA1-5) coding for proteins with both lipolytic and lipogenic properties. PNPLA3 has previously been associated with adult obesity. Here we investigated the possible association between genetic variants in these genes and childhood and adolescent obesity. Polymorphisms in the five genes of the adiponutrin gene family were selected and genotyped using the Sequenom platform in a childhood and adolescent obesity case-control study. Six variants in PNPLA1 showed association with obesity (rs9380559, rs12212459, rs1467912, rs4713951, rs10947600, and rs12199580, p<0.05 after adjustment for age and gender). Three variants in PNPLA3 showed association with obesity before, but not after, adjustment for age and gender (rs139051, rs12483959, and rs2072907, p>0.05). When analyzing these SNPs in relation to phenotypes, two SNPs in the PNPLA3 gene showed association with insulin sensitivity (rs12483959: beta = -0.053, p = 0.016, and rs2072907: beta = -0.049, p = 0.024). No associations were seen for PNPLA2, PNPLA4, and PNPLA5. Genetic variation in the adiponutrin gene family does not seem to contribute strongly to obesity in children and adolescents. PNPLA1 exhibited a modest effect on obesity and PNPLA3 on insulin sensitivity. These data, however, require confirmation in other cohorts and ethnic groups.

MeSH Terms
Adolescent Case-Control Studies Female Genetic Variation Genotype Humans Insulin Resistance/genetics Lipase/genetics,metabolism Male Membrane Proteins/genetics Obesity/genetics,metabolism Polymorphism, Single Nucleotide Proteins/genetics,metabolism
Chemicals
Membrane Proteins Proteins adiponutrin Lipase PNPLA2 protein, human PNPLA4 protein, human
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Johansson Lovisa E
Department of Clinical Sciences Malmö, Lund University, Lund, Sweden. [email protected]
Johansson Lina M
Danielsson Pernilla
Norgren Svante
Johansson Stina
Marcus Claude
Ridderstråle Martin
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0005327
Email
[email protected]
Published
2009-00-00
Epub
2009-00-24
Pages
e5327
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC2669125
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pone.0005327 PMC Full Text View journal details
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