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PMID: 19420049 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Detecting ancient admixture and estimating demographic parameters in multiple human populations.

Molecular biology and evolution ·Vol. 26 ·No. 8 ·2009-08-00 ·Pages 1823-7

Wall JD, Lohmueller KE, Plagnol V

Abstract

We analyze patterns of genetic variation in extant human polymorphism data from the National Institute of Environmental Health Sciences single nucleotide polymorphism project to estimate human demographic parameters. We update our previous work by considering a larger data set (more genes and more populations) and by explicitly estimating the amount of putative admixture between modern humans and archaic human groups (e.g., Neandertals, Homo erectus, and Homo floresiensis). We find evidence for this ancient admixture in European, East Asian, and West African samples, suggesting that admixture between diverged hominin groups may be a general feature of recent human evolution.

MeSH Terms
Africa, Western Animals Biological Evolution Europe Far East Genetics, Population Genome, Human Hominidae/genetics Humans Polymorphism, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wall Jeffrey D
Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California San Francisco, CA, USA. [email protected]
Lohmueller Kirk E
Plagnol Vincent
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Article Info
Journal
Molecular biology and evolution
Abbr.
Mol Biol Evol
ISSN
1537-1719
DOI
10.1093/molbev/msp096
Email
[email protected]
Published
2009-08-00
Epub
2009-00-06
Pages
1823-7
Language
English
Region
United States
NLM ID
8501455
PMCID
PMC2734152
Subset
IM
Grants
NHGRI NIH HHS · R01 HG004049 · United States
NHGRI NIH HHS · HG004049 · United States
External Links
PubMed source DOI: 10.1093/molbev/msp096 PMC Full Text View journal details
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