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PMID: 19486695 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cytoskeletal polymer networks: viscoelastic properties are determined by the microscopic interaction potential of cross-links.

Biophysical journal ·Vol. 96 ·No. 11 ·2009-06-03 ·Pages 4725-32

Lieleg O, Schmoller KM, Claessens MM, Bausch AR

Abstract

Although the structure of cross-linking molecules mainly determines the structural organization of actin filaments and with that the static elastic properties of the cytoskeleton, it is largely unknown how the biochemical characteristics of transiently cross-linking proteins (actin-binding proteins (ABPs)) affect the viscoelasticity of actin networks. In this study, we show that the macroscopic network response of reconstituted actin networks can be traced back to the microscopic interaction potential of an individual actin/ABP bond. The viscoelastic response of cross-linked actin networks is set by the cross-linker off-rate, the binding energy, and the characteristic bond length of individual actin/ABP interactions.

MeSH Terms
Actins/chemistry Animals Elasticity Microfilament Proteins/chemistry Models, Chemical Muscle, Skeletal/chemistry Myosin Subfragments/chemistry Rabbits Rheology Temperature Viscoelastic Substances/chemistry Viscosity
Chemicals
Actins Microfilament Proteins Myosin Subfragments Viscoelastic Substances
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lieleg O
Lehrstuhl für Zellbiophysik E27, Technische Universität München, Garching, Germany.
Schmoller K M
Claessens M M A E
Bausch A R
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Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
1542-0086
DOI
10.1016/j.bpj.2009.03.038
Published
2009-06-03
Pages
4725-32
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC2711496
Subset
IM
External Links
PubMed source DOI: 10.1016/j.bpj.2009.03.038 PMC Full Text View journal details
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