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PMID: 19580395 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mitochondrial regulation of cell survival and death during low-oxygen conditions.

Antioxidants & redox signaling ·Vol. 11 ·No. 11 ·2009-11-00 ·Pages 2673-83

Snyder CM, Chandel NS

Abstract

Mitochondria can initiate cell death or activate genes that promote cell survival in response to low oxygen. The BCL-2 family of proteins regulate cell death in response to anoxia (0-0.5% O2). By contrast, under hypoxia (0.5-3% O2), mitochondrial oxidative stress activates hypoxia-inducible factors (HIFs) to promote cell survival. In this review, we discuss how mitochondria, BCL-2 proteins, and HIFs are crucial for cellular responses to low oxygen.

MeSH Terms
Animals Cell Death/physiology Cell Hypoxia/physiology Cell Survival/physiology Humans Hypoxia-Inducible Factor 1/metabolism,physiology Mitochondria/metabolism Models, Biological Oxidative Stress/physiology Proto-Oncogene Proteins c-bcl-2/metabolism,physiology
Chemicals
Hypoxia-Inducible Factor 1 Proto-Oncogene Proteins c-bcl-2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Snyder Colleen M
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School , Chicago, Illinois, USA.
Chandel Navdeep S
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Article Info
Journal
Antioxidants & redox signaling
Abbr.
Antioxid Redox Signal
ISSN
1557-7716
DOI
10.1089/ars.2009.2730
Published
2009-11-00
Pages
2673-83
Language
English
Region
United States
NLM ID
100888899
PMCID
PMC2821141
Subset
IM
Grants
NCI NIH HHS · R01CA123067-03 · United States
External Links
PubMed source DOI: 10.1089/ars.2009.2730 PMC Full Text View journal details
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