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PMID: 19602472 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study.

Journal of epidemiology and community health ·Vol. 64 ·No. 1 ·2010-01-00 ·Pages 49-56

Ren C, Baccarelli A, Wilker E, Suh H, Sparrow D, Vokonas P, Wright R, Schwartz J

Abstract

Many studies have shown that exposures to air pollution are associated with cardiovascular events, although the mechanism remains to be clarified. To identify whether exposures to ambient particles act on autonomic function via the lipid/endothelial metabolism pathway, whether effects of particulate matter <2.5 mum in aerodynamic diameter (PM(2.5)) on heart rate variability (HRV) were modified by gene polymorphisms related to those pathways were evaluated. HRV and gene data from the Normative Aging Study and PM(2.5) from a monitor located a kilometre from the examination site were used. A mixed model was fitted to investigate the associations between PM(2.5) and repeated measurements of HRV by gene polymorphisms of apolipoprotein E (APOE), lipoprotein lipase (LPL) and vascular endothelial growth factor (VEGF) adjusting for potential confounders chosen a priori. A 10 microg/m(3) increase in PM(2.5) in the 2 days before the examination was associated with 3.8% (95% CI 0.2% to 7.4%), 7.8% (95 CI 0.4% to 15.3%) and 10.6% (95% CI 1.8% to 19.4%) decreases of the standard deviation of normal-to-normal intervals, the low frequency and the high frequency, respectively. Overall, carriers of wild-type APOE, LPL and VEGF genes had stronger effects of particles on HRV than those with hetero- or homozygous types. Variations of LPL-N291S, LPL-D9N and APOE-G113C significantly modified effects of PM(2.5) on HRV. Associations between PM(2.5) and HRV were modified by gene polymorphisms of APOE, LPL and VEGF; the biological metabolism remains to be identified.

MeSH Terms
Aged Aged, 80 and over Air Pollutants/pharmacology Apolipoproteins E/genetics Endothelium/metabolism Genotype Heart Rate/drug effects,genetics Humans Lipoprotein Lipase/genetics Longitudinal Studies Male Particulate Matter/pharmacology Polymorphism, Genetic Vascular Endothelial Growth Factor A/genetics
Chemicals
Air Pollutants Apolipoproteins E Particulate Matter Vascular Endothelial Growth Factor A Lipoprotein Lipase
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ren C
Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Landmark Center West, Suite 415, 401 Park Dr, Boston, MA 02215, USA. [email protected]
Baccarelli A
Wilker E
Suh H
Sparrow D
Vokonas P
Wright R
Schwartz J
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Article Info
Journal
Journal of epidemiology and community health
Abbr.
J Epidemiol Community Health
ISSN
1470-2738
DOI
10.1136/jech.2008.083295
Email
[email protected]
Published
2010-01-00
Pages
49-56
Language
English
Region
England
NLM ID
7909766
PMCID
PMC3935361
Subset
IM
Grants
NIEHS NIH HHS · R01 ES015172 · United States
NIEHS NIH HHS · R01 ES010798 · United States
NIEHS NIH HHS · ES00002 · United States
NIEHS NIH HHS · ES10798 · United States
NIEHS NIH HHS · P30 ES000002 · United States
NIEHS NIH HHS · P01_ES008925 · United States
NIEHS NIH HHS · P42-ES05947 · United States
NIEHS NIH HHS · P42 ES005947 · United States
NIEHS NIH HHS · ES05257 · United States
NIEHS NIH HHS · R01 ES005257 · United States
NIEHS NIH HHS · ES-014663 · United States
NIEHS NIH HHS · R01-ES015172 · United States
NIEHS NIH HHS · R01 ES014663 · United States
External Links
PubMed source DOI: 10.1136/jech.2008.083295 PMC Full Text View journal details
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