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PMID: 19625767 Published · ppublish English Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

Cell cycle (Georgetown, Tex.) ·Vol. 8 ·No. 16 ·2009-08-15 ·Pages 2664-6

Michishita E, McCord RA, Boxer LD, Barber MF, Hong T, Gozani O, Chua KF

Abstract

暂无摘要

MeSH Terms

Acetylation Cell Cycle/genetics,physiology Cell Line Cell Line, Tumor Histones/metabolism Humans Lysine/metabolism Mass Spectrometry Sirtuins/genetics,metabolism Telomere/metabolism

Chemicals

Histones SIRT6 protein, human Sirtuins Lysine

Authors & Affiliations

7 authors, click to expand affiliations / ORCID

Michishita Eriko

McCord Ronald A

Boxer Lisa D

Barber Matthew F

Hong Tao

Gozani Or

Chua Katrin F

References (16)

16 references, click to expand

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.
Nature. 2005 Jul 14;436(7048):294-8 PMID: 16015338
Acetylation in histone H3 globular domain regulates gene expression in yeast.
Cell. 2005 May 6;121(3):375-85 PMID: 15882620
Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells.
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CBP/p300-mediated acetylation of histone H3 on lysine 56.
Nature. 2009 May 7;459(7243):113-7 PMID: 19270680
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.
Science. 2007 Feb 2;315(5812):653-5 PMID: 17272723
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Cell. 2009 Jan 9;136(1):62-74 PMID: 19135889
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.
Nature. 2008 Mar 27;452(7186):492-6 PMID: 18337721
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.
Cell. 2008 Jul 25;134(2):231-43 PMID: 18662539
Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast.
Mol Cell. 2007 Sep 21;27(6):890-900 PMID: 17889663
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair.
Aging (Albany NY). 2009 Jan 15;1(1):109-21 PMID: 20157594
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56.
Science. 2007 Feb 2;315(5812):649-52 PMID: 17272722
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.
Curr Biol. 2006 Jul 11;16(13):1280-9 PMID: 16815704
Histone H3-K56 acetylation is important for genomic stability in mammals.
Cell Cycle. 2009 Jun 1;8(11):1747-53 PMID: 19411844
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.
Cell. 2006 Jan 27;124(2):315-29 PMID: 16439206
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.
Mol Cell. 2009 Feb 27;33(4):417-27 PMID: 19250903
Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.
Mol Cell. 2006 Jul 7;23(1):109-19 PMID: 16818235

Article Info

Journal

Cell cycle (Georgetown, Tex.)

Abbr.

Cell Cycle

ISSN

1551-4005

DOI

10.4161/cc.8.16.9367

Published

2009-08-15

Epub

2009-00-26

Pages

2664-6

Language

English

Region

United States

NLM ID

101137841

PMCID

PMC4474138

Subset

Grants

NIA NIH HHS · K08 AG028961 · United States

NCRR NIH HHS · P41 RR001614 · United States

NIA NIH HHS · R01 AG028867 · United States

NIGMS NIH HHS · R01 GM079641 · United States

External Links

PubMed source DOI: 10.4161/cc.8.16.9367 PMC Full Text View journal details

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Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

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