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PMID: 19639427 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Epigenetic perspectives in systemic lupus erythematosus: pathogenesis, biomarkers, and therapeutic potentials.

Clinical reviews in allergy & immunology ·Vol. 39 ·No. 1 ·2010-08-00 ·Pages 3-9

Zhao S, Long H, Lu Q

Abstract

System lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the production of autoantibodies that cause widespread tissue damage. The underlying etiology remains largely unknown. Aberrant epigenetics plays essential roles in the pathogenesis of SLE. This review explores the links between DNA methylation, histone modifications, and miRNAs in SLE and highlights how these factors may interact in SLE pathogenesis. We also discuss how furthering our knowledge of epigenetics in lupus provides hope for finding new diagnostic and prognostic biomarkers and novel therapeutic targets and strategies.

MeSH Terms
Animals Autoantibodies/immunology Biomarkers/metabolism Cytotoxicity, Immunologic DNA Methylation Epigenesis, Genetic Histones/immunology Humans Lupus Erythematosus, Systemic/diagnosis,genetics,immunology,metabolism,therapy MicroRNAs/genetics Prognosis Protein Processing, Post-Translational
Chemicals
Autoantibodies Biomarkers Histones MicroRNAs
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zhao Sha
Department of Dermatology, Epigenetic Research Center, Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, Hunan, 410011, People's Republic of China.
Long Hai
Lu Qianjin
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Article Info
Journal
Clinical reviews in allergy & immunology
Abbr.
Clin Rev Allergy Immunol
ISSN
1559-0267
DOI
10.1007/s12016-009-8165-7
Published
2010-08-00
Pages
3-9
Language
English
Region
United States
NLM ID
9504368
Subset
IM
External Links
PubMed source DOI: 10.1007/s12016-009-8165-7 View journal details
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