Amyloid + activation = Alzheimer's?

Neuron ·Vol. 63 ·No. 2 ·2009-07-30 ·Pages 141-3

Jagust W

Abstract

PET imaging of Alzheimer's disease (AD) patients demonstrates Abeta-protein accumulation in a default mode network. In this issue of Neuron, Sperling and colleagues show that cognitively intact individuals with Abeta in this network fail to deactivate it during memory tasks, a finding with important implications for cognitive aging and early detection of AD.

MeSH Terms

Aging Alzheimer Disease/diagnostic imaging,physiopathology,psychology Amyloid beta-Peptides/metabolism Brain/diagnostic imaging,metabolism,physiopathology Cognition Humans Magnetic Resonance Imaging Memory Neuropsychological Tests Positron-Emission Tomography

Chemicals

Amyloid beta-Peptides

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Jagust William

Helen Wills Neuroscience Institute, University of California, Berkeley, 132 Barker Hall, Berkeley, CA 94720-3190, USA. [email protected]

Article Info

Journal

Neuron

Abbr.

Neuron

ISSN

1097-4199

DOI

10.1016/j.neuron.2009.07.008

[email protected]

Published

2009-07-30

Pages

141-3

Language

English

Region

United States

NLM ID

8809320

Subset

Corrections

CommentOn

PMID: 19640477

External Links

PubMed source DOI: 10.1016/j.neuron.2009.07.008 View journal details

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