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PMID: 19640477 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Amyloid deposition is associated with impaired default network function in older persons without dementia.

Neuron ·Vol. 63 ·No. 2 ·2009-07-30 ·Pages 178-88

Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA

Abstract

Alzheimer's disease (AD) has been associated with functional alterations in a distributed network of brain regions linked to memory function, with a recent focus on the cortical regions collectively known as the default network. Posterior components of the default network, including the precuneus and posterior cingulate, are particularly vulnerable to early deposition of amyloid beta-protein, one of the hallmark pathologies of AD. In this study, we use in vivo amyloid imaging to demonstrate that high levels of amyloid deposition are associated with aberrant default network functional magnetic resonance imaging (fMRI) activity in asymptomatic and minimally impaired older individuals, similar to the pattern of dysfunction reported in AD patients. These findings suggest that amyloid pathology is linked to neural dysfunction in brain regions supporting memory function and provide support for the hypothesis that cognitively intact older individuals with evidence of amyloid pathology may be in early stages of AD.

MeSH Terms
Adult Aged Aged, 80 and over Amyloid beta-Peptides/metabolism Cognition Dementia/metabolism,pathology,physiopathology Female Hippocampus/metabolism,pathology,physiopathology,ultrastructure Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Microscopy, Electron Nerve Net/metabolism,pathology,physiopathology Neurons/ultrastructure
Chemicals
Amyloid beta-Peptides
Authors & Affiliations
13 authors, click to expand affiliations / ORCID
Sperling Reisa A
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. [email protected]
Laviolette Peter S
O'Keefe Kelly
O'Brien Jacqueline
Rentz Dorene M
Pihlajamaki Maija
Marshall Gad
Hyman Bradley T
Selkoe Dennis J
Hedden Trey
Buckner Randy L
Becker J Alex
Johnson Keith A
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2009.07.003
Email
[email protected]
Published
2009-07-30
Pages
178-88
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC2738994
Subset
IM
Grants
Howard Hughes Medical Institute · United States
NIA NIH HHS · R01AG027435 · United States
NIA NIH HHS · R01 AG027435 · United States
NIA NIH HHS · P50 AG005134 · United States
NIA NIH HHS · R01 AG021910-05 · United States
NIA NIH HHS · R01 AG034556 · United States
NIA NIH HHS · P50AG005134 · United States
NIA NIH HHS · R01 AG027435-04 · United States
NIA NIH HHS · P50 AG005134-268381 · United States
NIA NIH HHS · R01 AG034556-01 · United States
Corrections
CommentIn
PMID: 19640471
External Links
PubMed source DOI: 10.1016/j.neuron.2009.07.003 PMC Full Text View journal details
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