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PMID: 19736319 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.

The Journal of cell biology ·Vol. 186 ·No. 5 ·2009-09-07 ·Pages 739-53

García-Cortés JC, McCollum D

Abstract

Cytokinesis must be initiated only after chromosomes have been segregated in anaphase and must be terminated once cleavage is completed. We show that the fission yeast protein Etd1 plays a central role in both of these processes. Etd1 activates the guanosine triphosphatase (GTPase) Spg1 to trigger signaling through the septum initiation network (SIN) pathway and onset of cytokinesis. Spg1 is activated in late anaphase when spindle elongation brings spindle pole body (SPB)-localized Spg1 into proximity with its activator Etd1 at cell tips, ensuring that cytokinesis is only initiated when the spindle is fully elongated. Spg1 is active at just one of the two SPBs during cytokinesis. When the actomyosin ring finishes constriction, the SIN triggers disappearance of Etd1 from the half of the cell with active Spg1, which then triggers Spg1 inactivation. Asymmetric activation of Spg1 is crucial for timely inactivation of the SIN. Together, these results suggest a mechanism whereby cell asymmetry is used to monitor cytoplasmic partitioning to turn off cytokinesis signaling.

MeSH Terms
Anaphase/physiology Cell Cycle Proteins/genetics,metabolism Cytokinesis/physiology Enzyme Activation GTP Phosphohydrolases/genetics,metabolism Gene Knockdown Techniques Guanine Nucleotide Exchange Factors/genetics,metabolism Phenotype Protein Serine-Threonine Kinases/genetics,metabolism Recombinant Fusion Proteins/genetics,metabolism Saccharomyces cerevisiae Proteins/genetics,metabolism Schizosaccharomyces/cytology,genetics,metabolism Schizosaccharomyces pombe Proteins/genetics,metabolism Signal Transduction/physiology Spindle Apparatus/metabolism
Chemicals
Cell Cycle Proteins Etd1 protein, S pombe Guanine Nucleotide Exchange Factors LTE1 protein, S cerevisiae Recombinant Fusion Proteins Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins rlc1 protein, S pombe cdc7 protein, S pombe Protein Serine-Threonine Kinases GTP Phosphohydrolases Spg1 protein, S pombe
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
García-Cortés Juan Carlos
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
McCollum Dannel
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
1540-8140
Published
2009-09-07
Pages
739-53
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2742193
Subset
IM
Grants
NIGMS NIH HHS · R01 GM058406 · United States
NIGMS NIH HHS · GM058406 · United States
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