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PMID: 19741045 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Thyroid hormone receptors regulate adipogenesis and carcinogenesis via crosstalk signaling with peroxisome proliferator-activated receptors.

Journal of molecular endocrinology ·Vol. 44 ·No. 3 ·2010-03-00 ·Pages 143-54

Lu C, Cheng SY

Abstract

Peroxisome proliferator-activated receptors (PPARs) and thyroid hormone receptors (TRs) are members of the nuclear receptor superfamily. They are ligand-dependent transcription factors that interact with their cognate hormone response elements in the promoters to regulate respective target gene expression to modulate cellular functions. While the transcription activity of each is regulated by their respective ligands, recent studies indicate that via multiple mechanisms PPARs and TRs crosstalk to affect diverse biological functions. Here, we review recent advances in the understanding of the molecular mechanisms and biological impact of crosstalk between these two important nuclear receptors, focusing on their roles in adipogenesis and carcinogenesis.

MeSH Terms
Adipogenesis/genetics,physiology Animals Humans Models, Biological Neoplasms/genetics,metabolism Peroxisome Proliferator-Activated Receptors/genetics,metabolism Receptors, Thyroid Hormone/genetics,metabolism Signal Transduction/genetics,physiology
Chemicals
Peroxisome Proliferator-Activated Receptors Receptors, Thyroid Hormone
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lu Changxue
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892-4264, USA.
Cheng Sheue-Yann
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Article Info
Journal
Journal of molecular endocrinology
Abbr.
J Mol Endocrinol
ISSN
1479-6813
DOI
10.1677/JME-09-0107
Published
2010-03-00
Epub
2009-00-09
Pages
143-54
Language
English
Region
England
NLM ID
8902617
PMCID
PMC3464095
Subset
IM
Grants
Intramural NIH HHS · ZIA BC008752-30 · United States
External Links
PubMed source DOI: 10.1677/JME-09-0107 PMC Full Text View journal details
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