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PMID: 1974122 Published · ppublish English Journal Article Review

The fragile X: progress toward solving the puzzle.

American journal of human genetics ·Vol. 47 ·No. 2 ·1990-08-00 ·Pages 175-80

Brown WT

Abstract

暂无摘要

MeSH Terms
Female Fetal Diseases/diagnosis,genetics Fragile X Syndrome/diagnosis,genetics Humans Male Polymorphism, Restriction Fragment Length Pregnancy Prenatal Diagnosis Restriction Mapping Sex Chromosome Aberrations/genetics
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brown W T
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030.
References (31)
31 references, click to expand
  1. Genetic and physical mapping of a novel region close to the fragile X site on the human X chromosome.
    Genomics. 1989 May;4(4):570-8 PMID: 2744766
  2. Toward a physical map of the Xq28 region in man: linking color vision, G6PD, and coagulation factor VIII genes to an X-Y homology region.
    Genomics. 1989 May;4(4):460-71 PMID: 2501212
  3. The polymorphic marker DXS304 is within 5 centimorgans of the fragile X locus.
    Genomics. 1989 Nov;5(4):797-801 PMID: 2574147
  4. New polymorphic DNA marker close to the fragile site FRAXA.
    Genomics. 1990 Jan;6(1):129-32 PMID: 1968042
  5. Two progenitor cells for human oogonia inferred from pedigree data and the X-inactivation imprinting model of the fragile-X syndrome.
    Am J Hum Genet. 1990 Apr;46(4):696-719 PMID: 1969225
  6. Physical and genetic mapping of polymorphic loci in Xq28 (DXS15, DXS52, and DXS134): analysis of a cosmid clone and a yeast artificial chromosome.
    Am J Hum Genet. 1990 Apr;46(4):720-8 PMID: 1969226
  7. Mental retardation in heterozygotes for the fragile-X mutation: evidence in favor of an X inactivation-dependent effect.
    Am J Hum Genet. 1990 Apr;46(4):738-43 PMID: 2316520
  8. Methylation status of genes flanking the fragile site in males with the fragile-X syndrome: a test of the imprinting hypothesis.
    Am J Hum Genet. 1990 Apr;46(4):744-53 PMID: 2316521
  9. Microdissection of the fragile X region.
    Am J Hum Genet. 1990 Aug;47(2):181-6 PMID: 2378345
  10. Physical mapping of new DNA probes near the fragile X mutation (FRAXA) by using a panel of cell lines.
    Am J Hum Genet. 1990 Aug;47(2):187-95 PMID: 2378346
  11. Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.
    Science. 1977 Jul 15;197(4300):265-6 PMID: 877551
  12. X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.
    J Pediatr. 1980 May;96(5):837-41 PMID: 7189210
  13. The fragile X: a scanning electron microscope study.
    J Med Genet. 1983 Aug;20(4):280-5 PMID: 6684694
  14. The marker (X) syndrome: a cytogenetic and genetic analysis.
    Ann Hum Genet. 1984 Jan;48(Pt 1):21-37 PMID: 6712153
  15. Analysis of the fragile-X chromosome: localization and detection of the fragile site in high resolution preparations.
    Hum Genet. 1985;69(3):209-11 PMID: 4038969
  16. Further segregation analysis of the fragile X syndrome with special reference to transmitting males.
    Hum Genet. 1985;69(4):289-99 PMID: 3838733
  17. Frequency and replication status of the fragile X, fra(X)(q27-28), in a pair of monozygotic twins of markedly differing intelligence.
    J Med Genet. 1985 Apr;22(2):85-91 PMID: 4039370
  18. Population incidence and segregation ratios in the Martin-Bell syndrome.
    Am J Med Genet. 1986 Jan-Feb;23(1-2):573-80 PMID: 3953667
  19. Prevalence of the fragile-X syndrome in mentally retarded boys in a Swedish county.
    Am J Med Genet. 1986 Jan-Feb;23(1-2):581-7 PMID: 3953668
  20. Mapping of DNA markers close to the fragile site on the human X chromosome at Xq27.3.
    Nucleic Acids Res. 1987 Mar 25;15(6):2639-51 PMID: 2882476
  21. Further evidence for genetic heterogeneity in the fragile X syndrome.
    Hum Genet. 1987 Apr;75(4):311-21 PMID: 2883105
  22. The fragile X site in somatic cell hybrids: an approach for molecular cloning of fragile sites.
    Science. 1987 Jul 24;237(4813):420-3 PMID: 3603029
  23. Proposed mechanism of inheritance and expression of the human fragile-X syndrome of mental retardation.
    Genetics. 1987 Nov;117(3):587-99 PMID: 3692144
  24. Multilocus analysis of the fragile X syndrome.
    Hum Genet. 1988 Mar;78(3):201-5 PMID: 3162224
  25. Physical mapping studies on the human X chromosome in the region Xq27-Xqter.
    Genomics. 1987 Dec;1(4):297-306 PMID: 3482420
  26. Recent experience in prenatal fra(X) detection.
    Am J Med Genet. 1988 May-Jun;30(1-2):329-36 PMID: 2972205
  27. Pulsed-field gradient-gel studies around the fragile site.
    Am J Med Genet. 1988 May-Jun;30(1-2):593-600 PMID: 2902798
  28. Cytogenetic and physical mapping in the region of the X chromosome surrounding the fragile site.
    Am J Med Genet. 1988 May-Jun;30(1-2):601-11 PMID: 2902799
  29. Physical mapping of DXS134 close to the DXS52 locus.
    Hum Genet. 1989 Apr;82(1):27-30 PMID: 2565864
  30. Isolation of a DNA probe of potential use for diagnosis of the fragile-X syndrome.
    Hum Genet. 1989 Jun;82(3):216-8 PMID: 2567272
  31. Linkage analysis of families with fragile-X mental retardation, using a novel RFLP marker (DXS 304).
    Am J Hum Genet. 1989 Aug;45(2):304-9 PMID: 2569270
Article Info
Journal
American journal of human genetics
Abbr.
Am J Hum Genet
ISSN
0002-9297
Published
1990-08-00
Pages
175-80
Language
English
Region
United States
NLM ID
0370475
PMCID
PMC1683734
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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