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PMID: 19754444 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Dissecting dynamin's role in clathrin-mediated endocytosis.

Biochemical Society transactions ·Vol. 37 ·No. Pt 5 ·2009-10-00 ·Pages 1022-6

Mettlen M, Pucadyil T, Ramachandran R, Schmid SL

Abstract

The GTPase dynamin is essential for CME (clathrin-mediated endocytosis), but its exact function and mechanism of action have been controversial. Here, we review findings that have led to the current models for dynamin function, either as a mechanochemical enzyme driving membrane fission or as a regulatory GTPase monitoring rate-limiting steps in CME. However, these models are not mutually exclusive and subsequent studies have provided evidence for both dynamin functions. Recent evidence derived from divergent in vivo and in vitro approaches suggests that dynamin plays a dual role in CME, functioning at early stages as a fidelity monitor to regulate clathrin-coated pit maturation and at later stages to directly catalyse membrane fission and clathrin-coated vesicle formation.

MeSH Terms
Animals Clathrin/metabolism Dynamins/genetics,metabolism Endocytosis/physiology GTP Phosphohydrolases/metabolism Intracellular Membranes/metabolism Microtubules/metabolism
Chemicals
Clathrin GTP Phosphohydrolases Dynamins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Mettlen Marcel
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Pucadyil Thomas
Ramachandran Rajesh
Schmid Sandra L
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Article Info
Journal
Biochemical Society transactions
Abbr.
Biochem Soc Trans
ISSN
1470-8752
Published
2009-10-00
Pages
1022-6
Language
English
Region
England
NLM ID
7506897
PMCID
PMC2879887
Subset
IM
Grants
NIGMS NIH HHS · R01 GM073165-06 · United States
NIMH NIH HHS · R37 MH061345 · United States
NIMH NIH HHS · MH61345 · United States
NIMH NIH HHS · R01 MH061345 · United States
NIMH NIH HHS · R37 MH061345-10 · United States
NIGMS NIH HHS · R01 GM042455-21 · United States
NIGMS NIH HHS · GM42455 · United States
NIGMS NIH HHS · GM73165 · United States
NIGMS NIH HHS · R01 GM042455 · United States
NIGMS NIH HHS · R01 GM073165 · United States
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