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PMID: 19829370 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Neuroscience in the era of functional genomics and systems biology.

Nature ·Vol. 461 ·No. 7266 ·2009-10-15 ·Pages 908-15

Geschwind DH, Konopka G

Abstract

Advances in genetics and genomics have fuelled a revolution in discovery-based, or hypothesis-generating, research that provides a powerful complement to the more directly hypothesis-driven molecular, cellular and systems neuroscience. Genetic and functional genomic studies have already yielded important insights into neuronal diversity and function, as well as disease. One of the most exciting and challenging frontiers in neuroscience involves harnessing the power of large-scale genetic, genomic and phenotypic data sets, and the development of tools for data integration and mining. Methods for network analysis and systems biology offer the promise of integrating these multiple levels of data, connecting molecular pathways to nervous system function.

MeSH Terms
Animals Gene Expression Profiling Genomics/methods Humans Nervous System/metabolism Neurosciences/methods,trends Proteome/metabolism Synapses/metabolism Systems Biology/methods
Chemicals
Proteome
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Geschwind Daniel H
Program in Neurogenetics and Neurobehavioural Genetics, Department of Neurology and Semel Institute, David Geffen School of Medicine, Los Angeles, California 90095, USA. [email protected]
Konopka Genevieve
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature08537
Email
[email protected]
Published
2009-10-15
Pages
908-15
Language
English
Region
England
NLM ID
0410462
PMCID
PMC3645852
Subset
IM
Grants
NIMH NIH HHS · K99 MH090238 · United States
NINDS NIH HHS · U24 NS52108 · United States
NIMH NIH HHS · R37 MH060233 · United States
NIMH NIH HHS · R37 MH60233-06A1 · United States
NINDS NIH HHS · U24 NS052108 · United States
External Links
PubMed source DOI: 10.1038/nature08537 PMC Full Text View journal details
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