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PMID: 19844227 Published · ppublish English Journal Article Review

Next-generation gap.

Nature methods ·Vol. 6 ·No. 11 Suppl ·2009-11-00 ·Pages S2-5

McPherson JD

Abstract

There is a growing gap between the generation of massively parallel sequencing output and the ability to process and analyze the resulting data. New users are left to navigate a bewildering maze of base calling, alignment, assembly and analysis tools with often incomplete documentation and no idea how to compare and validate their outputs. Bridging this gap is essential, or the coveted $1,000 genome will come with a $20,000 analysis price tag.

MeSH Terms
Base Sequence Genetic Variation Genome Humans Sequence Alignment/methods Sequence Analysis, DNA/instrumentation,methods Software
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
McPherson John D
Ontario Institute for Cancer Research, Toronto, Ontario, Canada. [email protected]
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Article Info
Journal
Nature methods
Abbr.
Nat Methods
ISSN
1548-7105
DOI
10.1038/nmeth.f.268
Email
[email protected]
Published
2009-11-00
Pages
S2-5
Language
English
Region
United States
NLM ID
101215604
Subset
IM
External Links
PubMed source DOI: 10.1038/nmeth.f.268 View journal details
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