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PMID: 19857593 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Stroma in breast development and disease.

Seminars in cell & developmental biology ·Vol. 21 ·No. 1 ·2010-02-00 ·Pages 11-8

Arendt LM, Rudnick JA, Keller PJ, Kuperwasser C

Abstract

It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence.

MeSH Terms
Animals Breast/anatomy & histology,growth & development,pathology Breast Neoplasms/pathology,physiopathology Cell Transformation, Neoplastic Connective Tissue/anatomy & histology,pathology Disease Progression Female Fibrosis/pathology Humans Stromal Cells/cytology,pathology,physiology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Arendt Lisa M
Department of Anatomy & Cellular Biology, Sackler School, Tufts University School of Medicine, Boston, MA 02111, USA.
Rudnick Jenny A
Keller Patricia J
Kuperwasser Charlotte
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Article Info
Journal
Seminars in cell & developmental biology
Abbr.
Semin Cell Dev Biol
ISSN
1096-3634
DOI
10.1016/j.semcdb.2009.10.003
Published
2010-02-00
Epub
2009-00-24
Pages
11-8
Language
English
Region
England
NLM ID
9607332
PMCID
PMC2823823
Subset
IM
Grants
NCI NIH HHS · R01 CA125554-01 · United States
NCRR NIH HHS · K01 RR021858 · United States
NCRR NIH HHS · K01-RR021858 · United States
NCI NIH HHS · R01CA125554 · United States
NCI NIH HHS · R01 CA125554 · United States
External Links
PubMed source DOI: 10.1016/j.semcdb.2009.10.003 PMC Full Text View journal details
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