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PMID: 19909357 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of lymphocyte development and activation by the LAT family of adapter proteins.

Immunological reviews ·Vol. 232 ·No. 1 ·2009-11-00 ·Pages 72-83

Fuller DM, Zhang W

Abstract

Transmembrane adapter proteins (TRAPs) are critical components of signaling pathways in lymphocytes, linking antigen receptor engagement to downstream cellular processes. While these proteins lack intrinsic enzymatic activity, their phosphorylation following receptor ligation allows them to function as scaffolds for the assembly of multi-molecular signaling complexes. Many TRAPs have recently been discovered, and numerous studies demonstrate their roles in the positive and negative regulation of lymphocyte maturation, activation, and differentiation. One such example is the linker for activation of T cells (LAT) family of adapter proteins. While LAT has been shown to play an indispensable role in T-cell and mast cell function, the other family members, linker for activation of B cells (LAB) and linker for activation of X cells (LAX), are necessary to fine-tune immune responses. In addition to its well-established role in the positive regulation of lymphocyte activation, LAT exerts an inhibitory effect on T-cell receptor-mediated signaling. Furthermore, LAT, along with LAB and LAX, plays a crucial role in establishing and maintaining tolerance. Here, we review recent data concerning the regulation of lymphocyte development and activation by the LAT family of proteins.

MeSH Terms
Adaptor Proteins, Signal Transducing/immunology,metabolism Adaptor Proteins, Vesicular Transport/immunology,metabolism Animals Feedback, Physiological Humans Immunity, Cellular Lymphocyte Activation Membrane Proteins/immunology,metabolism Receptors, Antigen, T-Cell/metabolism Signal Transduction/immunology
Chemicals
Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport LAT protein, human LAT2 protein, human LAX1 protein, human Membrane Proteins Receptors, Antigen, T-Cell
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fuller Deirdre M
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Zhang Weiguo
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Article Info
Journal
Immunological reviews
Abbr.
Immunol Rev
ISSN
1600-065X
DOI
10.1111/j.1600-065X.2009.00828.x
Published
2009-11-00
Pages
72-83
Language
English
Region
England
NLM ID
7702118
PMCID
PMC3646374
Subset
IM
Grants
NIAID NIH HHS · R01 AI093717 · United States
NIAID NIH HHS · R01 AI056156 · United States
NIAID NIH HHS · AI056156 · United States
NIAID NIH HHS · AI048674 · United States
NIAID NIH HHS · R56 AI048674 · United States
NIAID NIH HHS · R01 AI048674 · United States
NIAID NIH HHS · R56 AI056156 · United States
External Links
PubMed source DOI: 10.1111/j.1600-065X.2009.00828.x PMC Full Text View journal details
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