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PMID: 19955394 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Review

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways.

Carcinogenesis ·Vol. 31 ·No. 1 ·2010-01-00 ·Pages 37-49

Schetter AJ, Heegaard NH, Harris CC

Abstract

Chronic inflammation and infection are major causes of cancer. There are continued improvements to our understanding of the molecular connections between inflammation and cancer. Key mediators of inflammation-induced cancer include nuclear factor kappa B, reactive oxygen and nitrogen species, inflammatory cytokines, prostaglandins and specific microRNAs. The collective activity of these mediators is largely responsible for either a pro-tumorigenic or anti-tumorigenic inflammatory response through changes in cell proliferation, cell death, cellular senescence, DNA mutation rates, DNA methylation and angiogenesis. As our understanding grows, inflammatory mediators will provide opportunities to develop novel diagnostic and therapeutic strategies. In this review, we provide a general overview of the connection between inflammation, microRNAs and cancer and highlight how our improved understanding of these connections may provide novel preventive, diagnostic and therapeutic strategies to reduce the health burden of cancer.

MeSH Terms
Animals Cytokines/metabolism Free Radicals/metabolism Humans Inflammation/genetics,metabolism MicroRNAs/genetics Neoplasms/genetics,metabolism Tumor Suppressor Protein p53/metabolism
Chemicals
Cytokines Free Radicals MicroRNAs Tumor Suppressor Protein p53
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schetter Aaron J
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Heegaard Niels H H
Harris Curtis C
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Article Info
Journal
Carcinogenesis
Abbr.
Carcinogenesis
ISSN
1460-2180
DOI
10.1093/carcin/bgp272
Published
2010-01-00
Epub
2009-00-02
Pages
37-49
Language
English
Region
England
NLM ID
8008055
PMCID
PMC2802675
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1093/carcin/bgp272 PMC Full Text View journal details
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