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PMID: 1997422 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Plasmodium falciparum ring-infected erythrocyte surface antigen is released from merozoite dense granules after erythrocyte invasion.

Infection and immunity ·Vol. 59 ·No. 3 ·1991-03-00 ·Pages 1183-7

Culvenor JG, Day KP, Anders RF

Abstract

Electron microscopy was used to study the fate of Plasmodium falciparum ring-infected erythrocyte surface antigen after merozoite invasion by using postembedding immunolabeling. The antigen was localized to small dense granules located centrally or laterally in free merozoites. In newly invaded erythrocytes, labeling was found in pockets of the parasitophorous vacuole space or in aggregates closely associated with the parasitophorous vacuole. These patterns indicate that ring-infected erythrocyte surface antigen is contained in merozoite dense granules that are released after merozoite invasion and not via apical rhoptry ducts at the time of merozoite attachment.

MeSH Terms
Animals Antibodies, Monoclonal Antigens, Surface/metabolism Cytoplasmic Granules Erythrocytes/parasitology,ultrastructure Immunoblotting Immunohistochemistry Mice Plasmodium falciparum/immunology,metabolism,ultrastructure Protozoan Proteins
Chemicals
Antibodies, Monoclonal Antigens, Surface Protozoan Proteins ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Culvenor J G
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Day K P
Anders R F
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.59.3.1183-1187.1991
Published
1991-03-00
Pages
1183-7
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258387
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.59.3.1183-1187.1991 PMC Full Text View journal details
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