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PMID: 20051636 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Progress toward the clinical application of patient-specific pluripotent stem cells.

The Journal of clinical investigation ·Vol. 120 ·No. 1 ·2010-01-00 ·Pages 51-9

Kiskinis E, Eggan K

Abstract

Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. These cells, just like embryonic stem cells, are likely to have a major impact on regenerative medicine, because they self-renew and retain the potential to be differentiated into all cell types of the human body. In this Review, we describe the current state of iPS cell technology, including approaches by which they are generated and what is known about their biology, and discuss the potential applications of these cells for disease modeling, drug discovery, and, eventually, cell replacement therapy.

MeSH Terms
Amyotrophic Lateral Sclerosis/therapy Animals Cell Differentiation Drug Discovery Embryonic Stem Cells/physiology,transplantation Humans Mice Parkinson Disease/therapy Pluripotent Stem Cells/physiology,transplantation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kiskinis Evangelos
The Stowers Medical Institute, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA. [email protected]
Eggan Kevin
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
1558-8238
DOI
10.1172/JCI40553
Email
[email protected]
Published
2010-01-00
Pages
51-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC2798698
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1172/JCI40553 PMC Full Text View journal details
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