Home LiteratureArticle Details
PMID: 20123075 Published · ppublish English Journal Article Review

High-mobility group box 1 and cancer.

Biochimica et biophysica acta ·Vol. 1799 ·No. 1-2 ·2010-00-00 ·Pages 131-40

Tang D, Kang R, Zeh HJ, Lotze MT

Abstract

High-mobility group box 1 protein (HMGB1), a chromatin associated nuclear protein and extracellular damage associated molecular pattern molecule (DAMP), is an evolutionarily ancient and critical regulator of cell death and survival. Overexpression of HMGB1 is associated with each of the hallmarks of cancer including unlimited replicative potential, ability to develop blood vessels (angiogenesis), evasion of programmed cell death (apoptosis), self-sufficiency in growth signals, insensitivity to inhibitors of growth, inflammation, tissue invasion and metastasis. Our studies and those of our colleagues suggest that HMGB1 is central to cancer (abnormal wound healing) and many of the findings in normal wound healing as well. Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1.

MeSH Terms
Animals Cell Nucleus/metabolism HMGB1 Protein/chemistry,genetics,metabolism Humans NF-kappa B/metabolism Neoplasms/blood supply,metabolism,pathology,therapy Receptors, Estrogen/metabolism Tumor Suppressor Proteins/metabolism
Chemicals
HMGB1 Protein NF-kappa B Receptors, Estrogen Tumor Suppressor Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tang Daolin
The DAMP Laboratory, Department of Surgery, G.27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Ave., Pittsburgh, PA 15213, USA.
Kang Rui
Zeh Herbert J
Lotze Michael T
References (157)
157 references, click to expand
  1. Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer.
    Oncol Rep. 2003 Mar-Apr;10(2):445-8 PMID: 12579287
  2. Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin.
    Proc Natl Acad Sci U S A. 2000 May 23;97(11):5768-72 PMID: 10811891
  3. Masquerader: high mobility group box-1 and cancer.
    Clin Cancer Res. 2007 May 15;13(10):2836-48 PMID: 17504981
  4. Serum high mobility group box chromosomal protein 1 is associated with clinicopathologic features in patients with hepatocellular carcinoma.
    Dig Liver Dis. 2008 Jun;40(6):446-52 PMID: 18294942
  5. Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature.
    Blood. 2006 Oct 1;108(7):2339-48 PMID: 16794251
  6. HMGB1 mediates endogenous TLR2 activation and brain tumor regression.
    PLoS Med. 2009 Jan 13;6(1):e10 PMID: 19143470
  7. Depletion of tumor-infiltrating macrophages is associated with amphoterin expression in colon cancer.
    Pathobiology. 2004;71(3):129-36 PMID: 15051925
  8. HMGB1 interacts differentially with members of the Rel family of transcription factors.
    Biochem Biophys Res Commun. 2003 Mar 7;302(2):421-6 PMID: 12604365
  9. Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain.
    Pharmacol Res. 2001 Mar;43(3):257-63 PMID: 11401418
  10. Addicted to death: invasive cancer and the immune response to unscheduled cell death.
    J Immunother. 2005 Jan-Feb;28(1):1-9 PMID: 15614039
  11. HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.
    J Biol Chem. 2002 Mar 1;277(9):7157-64 PMID: 11748232
  12. KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS.
    Shock. 2008 Sep;30(3):260-6 PMID: 18197146
  13. Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage.
    Mol Cancer Ther. 2009 Apr;8(4):864-72 PMID: 19372559
  14. Variation of HMGB1 expression in breast cancer.
    Anticancer Res. 2001 Nov-Dec;21(6A):3881-5 PMID: 11911263
  15. The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteins.
    Methods Cell Biol. 1977;16:257-67 PMID: 886981
  16. The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate.
    Transplant Proc. 2008 Sep;40(7):2136-8 PMID: 18790172
  17. C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions.
    Cancer Res. 2005 Mar 15;65(6):2097-107 PMID: 15781619
  18. Short hairpin RNA (shRNA) constructs targeting high mobility group box-1 (HMGB1) expression leads to inhibition of prostate cancer cell survival and apoptosis.
    Int J Oncol. 2009 Feb;34(2):425-31 PMID: 19148477
  19. Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation.
    J Cell Biol. 2004 Feb 2;164(3):441-9 PMID: 14744997
  20. Immunogenicity of 56 degrees C and UVC-treated prostate cancer is associated with release of HSP70 and HMGB1 from necrotic cells.
    Prostate. 2009 Sep 1;69(12):1343-52 PMID: 19496055
  21. Inflammation and necrosis promote tumour growth.
    Nat Rev Immunol. 2004 Aug;4(8):641-8 PMID: 15286730
  22. The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells.
    J Cell Biol. 2001 Mar 19;152(6):1197-206 PMID: 11257120
  23. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-alpha production in murine macrophages.
    Int J Immunopharmacol. 1999 Jul;21(7):435-43 PMID: 10454017
  24. HMG-1 as a late mediator of endotoxin lethality in mice.
    Science. 1999 Jul 9;285(5425):248-51 PMID: 10398600
  25. High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage.
    Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10320-5 PMID: 18650382
  26. High-mobility group (HMG) protein HMG-1 and TATA-binding protein-associated factor TAF(II)30 affect estrogen receptor-mediated transcriptional activation.
    Mol Endocrinol. 1997 Jul;11(8):1009-19 PMID: 9212049
  27. The expression of high-mobility group protein box 1 correlates with the progression of non-small cell lung cancer.
    Oncol Rep. 2009 Sep;22(3):535-9 PMID: 19639200
  28. Role of HMGB1 in apoptosis-mediated sepsis lethality.
    J Exp Med. 2006 Jul 10;203(7):1637-42 PMID: 16818669
  29. Tolerance, danger, and the extended family.
    Annu Rev Immunol. 1994;12:991-1045 PMID: 8011301
  30. Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.
    Immunity. 2008 Jul 18;29(1):21-32 PMID: 18631454
  31. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1).
    Angiogenesis. 2008;11(1):91-9 PMID: 18264787
  32. Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins.
    Nature. 1999 Jun 17;399(6737):708-12 PMID: 10385126
  33. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein.
    J Biol Chem. 2004 Feb 27;279(9):7370-7 PMID: 14660645
  34. Non-Hodgkin lymphoma expressing high levels of the danger-signalling protein HMGB1.
    Leuk Lymphoma. 2008 Jun;49(6):1184-9 PMID: 18569640
  35. The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer.
    Int J Cancer. 2007 Sep 1;121(5):1072-8 PMID: 17487845
  36. Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule.
    Am J Pathol. 2005 Apr;166(4):1259-63 PMID: 15793304
  37. Serum high mobility group box protein 1 as a clinical marker for non-small cell lung cancer.
    Respir Med. 2009 Dec;103(12):1949-53 PMID: 19535236
  38. Age-dependent change of HMGB1 and DNA double-strand break accumulation in mouse brain.
    Biochem Biophys Res Commun. 2008 Nov 7;376(1):128-33 PMID: 18762169
  39. HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis.
    Rheum Dis Clin North Am. 2004 Aug;30(3):627-37, xi PMID: 15261345
  40. Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis.
    Arthritis Res Ther. 2008;10(1):R1 PMID: 18179697
  41. Interaction with p53 enhances binding of cisplatin-modified DNA by high mobility group 1 protein.
    J Biol Chem. 2001 Mar 9;276(10):7534-40 PMID: 11106654
  42. Proteomic analysis of Tiam1-mediated metastasis in colorectal cancer.
    Cell Biol Int. 2007 Aug;31(8):805-14 PMID: 17376711
  43. Effects of HMGB-1 overexpression on cell-cycle progression in MCF-7 cells.
    J Korean Med Sci. 2004 Jun;19(3):321-6 PMID: 15201494
  44. Activation of gene expression in human neutrophils by high mobility group box 1 protein.
    Am J Physiol Cell Physiol. 2003 Apr;284(4):C870-9 PMID: 12620891
  45. Growth suppression and radiosensitivity increase by HMGB1 in breast cancer.
    Acta Pharmacol Sin. 2007 Dec;28(12):1957-67 PMID: 18031610
  46. Telomeres: cancer to human aging.
    Annu Rev Cell Dev Biol. 2006;22:531-57 PMID: 16824017
  47. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases.
    Nature. 2000 May 18;405(6784):354-60 PMID: 10830965
  48. Histidine-rich glycoprotein inhibited high mobility group box 1 in complex with heparin-induced angiogenesis in matrigel plug assay.
    Eur J Pharmacol. 2009 Nov 25;623(1-3):89-95 PMID: 19786011
  49. Differential effects between amphoterin and advanced glycation end products on colon cancer cells.
    Int J Cancer. 2003 May 10;104(6):722-7 PMID: 12640679
  50. [Enhancive effect of HMGB1 gene silence on adriamycin-induced apoptosis in K562/A02 drug resistance leukemia cells].
    Zhonghua Xue Ye Xue Za Zhi. 2008 Aug;29(8):549-52 PMID: 19112920
  51. Quercetin decreases oxidative stress, NF-kappaB activation, and iNOS overexpression in liver of streptozotocin-induced diabetic rats.
    J Nutr. 2005 Oct;135(10):2299-304 PMID: 16177186
  52. At the crossroads of necrosis and apoptosis: signaling to multiple cellular targets by HMGB1.
    Sci STKE. 2002 Sep 24;2002(151):pe39 PMID: 12297673
  53. Therapeutic potential of HMGB1-targeting agents in sepsis.
    Expert Rev Mol Med. 2008 Nov 04;10:e32 PMID: 18980707
  54. Structural features of the HMG chromosomal proteins and their genes.
    Biochim Biophys Acta. 1990 Jul 30;1049(3):231-43 PMID: 2200521
  55. The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy.
    Immunol Rev. 2007 Dec;220:47-59 PMID: 17979839
  56. Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer.
    J Transl Med. 2009 May 28;7:38 PMID: 19476625
  57. Regulation of HMGB1 release by autophagy.
    Autophagy. 2009 Feb;5(2):247-9 PMID: 19098461
  58. Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins.
    Nature. 1990 Apr 26;344(6269):830-6 PMID: 2330041
  59. Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression.
    Biochem J. 2003 Apr 15;371(Pt 2):301-10 PMID: 12534345
  60. A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.
    Cancer Res. 2003 Jan 1;63(1):100-6 PMID: 12517784
  61. p73: Friend or foe in tumorigenesis.
    Nat Rev Cancer. 2002 Aug;2(8):605-15 PMID: 12154353
  62. Heat shock response inhibits release of high mobility group box 1 protein induced by endotoxin in murine macrophages.
    Shock. 2005 May;23(5):434-40 PMID: 15834309
  63. Acetylated HMG1 protein interacts specifically with homologous DNA polymerase alpha in vitro.
    Biochem Biophys Res Commun. 1988 Aug 15;154(3):918-27 PMID: 3044369
  64. Telomeres and human disease: ageing, cancer and beyond.
    Nat Rev Genet. 2005 Aug;6(8):611-22 PMID: 16136653
  65. Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS.
    Neurotoxicology. 2006 Jan;27(1):22-30 PMID: 16125245
  66. Liposomal Ag engrafted with peptides of sequence derived from HMGB1 induce potent Ag-specific and anti-tumour immunity.
    Vaccine. 2009 Sep 25;27(42):5846-54 PMID: 19660589
  67. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling.
    J Immunol. 2007 May 15;178(10):6573-80 PMID: 17475888
  68. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal.
    Nat Rev Immunol. 2005 Apr;5(4):331-42 PMID: 15803152
  69. Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines.
    Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2320-5 PMID: 15374849
  70. Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype.
    Mol Cell Biol. 2003 Apr;23(8):2991-8 PMID: 12665595
  71. The acidic C-terminal domain and A-box of HMGB-1 regulates p53-mediated transcription.
    Nucleic Acids Res. 2003 Jun 15;31(12):3236-47 PMID: 12799451
  72. [Role of high mobility group box 1 in adriamycin-induced apoptosis in leukemia K562 cells].
    Ai Zheng. 2008 Sep;27(9):929-33 PMID: 18799030
  73. Clinical value of serum HMGB1 levels in early detection of recurrent squamous cell carcinoma of uterine cervix: comparison with serum SCCA, CYFRA21-1, and CEA levels.
    Croat Med J. 2009 Oct;50(5):455-64 PMID: 19839069
  74. Colon cancer cell-derived high mobility group 1/amphoterin induces growth inhibition and apoptosis in macrophages.
    Am J Pathol. 2005 Mar;166(3):751-60 PMID: 15743787
  75. Amphoterin induction in prostatic stromal cells by androgen deprivation is associated with metastatic prostate cancer.
    Oncol Rep. 2003 Nov-Dec;10(6):1863-8 PMID: 14534709
  76. The plasticity of estrogen receptor-DNA complexes: binding affinity and specificity of estrogen receptors to estrogen response element half-sites separated by variant spacers.
    J Steroid Biochem Mol Biol. 2008 May;110(1-2):186-95 PMID: 18479910
  77. Antioxidants and cancer, part 3: quercetin.
    Altern Med Rev. 2000 Jun;5(3):196-208 PMID: 10869101
  78. Immunogenic cell death modalities and their impact on cancer treatment.
    Apoptosis. 2009 Apr;14(4):364-75 PMID: 19145485
  79. HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.
    Mol Carcinog. 2009 Jul;48(7):571-80 PMID: 19360789
  80. HMGB1 loves company.
    J Leukoc Biol. 2009 Sep;86(3):573-6 PMID: 19414536
  81. HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism.
    J Immunol. 2009 May 1;182(9):5800-9 PMID: 19380828
  82. Ethyl pyruvate administration inhibits hepatic tumor growth.
    J Leukoc Biol. 2009 Sep;86(3):599-607 PMID: 19584311
  83. Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.
    J Clin Invest. 2004 Jun;113(11):1641-50 PMID: 15173891
  84. High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy.
    J Immunother. 2007 Sep;30(6):596-606 PMID: 17667523
  85. Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development.
    Prostate. 2005 Jun 15;64(1):92-100 PMID: 15666359
  86. Mechanism of repression of RNA polymerase I transcription by the retinoblastoma protein.
    Mol Cell Biol. 1997 Aug;17(8):4230-7 PMID: 9234680
  87. Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury.
    Hepatology. 2009 Aug;50(2):565-74 PMID: 19492424
  88. Damage associated molecular pattern molecules.
    Clin Immunol. 2007 Jul;124(1):1-4 PMID: 17468050
  89. Cancer-related inflammation.
    Nature. 2008 Jul 24;454(7203):436-44 PMID: 18650914
  90. High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops.
    Biochemistry. 2004 Jun 8;43(22):7215-25 PMID: 15170359
  91. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy.
    Nat Med. 2007 Sep;13(9):1050-9 PMID: 17704786
  92. Calnexin is involved in apoptosis induced by endoplasmic reticulum stress in the fission yeast.
    Mol Biol Cell. 2008 Oct;19(10):4404-20 PMID: 18701708
  93. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages.
    J Immunol. 2007 Jul 15;179(2):1236-44 PMID: 17617616
  94. HMGB1 inhibits cell death in yeast and mammalian cells and is abundantly expressed in human breast carcinoma.
    FASEB J. 2003 Jul;17(10):1295-7 PMID: 12759333
  95. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.
    Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12351-6 PMID: 12209006
  96. Differences between HMG1 proteins isolated from normal and tumour cells.
    Biochim Biophys Acta. 1987 Oct 15;915(3):399-405 PMID: 3651478
  97. HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.
    Nature. 2009 Nov 5;462(7269):99-103 PMID: 19890330
  98. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
    Nat Immunol. 2007 May;8(5):487-96 PMID: 17417641
  99. Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer.
    Biochem Biophys Res Commun. 2007 Aug 24;360(2):394-400 PMID: 17599806
  100. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.
    J Biol Chem. 2002 Mar 1;277(9):7021-8 PMID: 11748221
  101. HMGB1: a two-headed signal regulating tumor progression and immunity.
    Curr Opin Immunol. 2008 Oct;20(5):518-23 PMID: 18599281
  102. Expression of receptor for advanced glycation end products and HMGB1/amphoterin in colorectal adenomas.
    Virchows Arch. 2005 Apr;446(4):411-5 PMID: 15789216
  103. HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail.
    Int J Biochem Cell Biol. 2008;40(8):1536-42 PMID: 18191612
  104. Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells.
    Hum Exp Toxicol. 2009 Aug;28(8):493-503 PMID: 19755441
  105. High mobility group protein B1 is an activator of apoptotic response to antimetabolite drugs.
    Mol Pharmacol. 2008 Jan;73(1):260-9 PMID: 17951356
  106. A pilot study to detect high mobility group box 1 and heat shock protein 72 in cerebrospinal fluid of pediatric patients with meningitis.
    Crit Care Med. 2008 Jan;36(1):291-5 PMID: 18090368
  107. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.
    Science. 2009 Mar 27;323(5922):1722-5 PMID: 19264983
  108. Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1.
    J Virol. 2003 Nov;77(22):12243-51 PMID: 14581561
  109. High mobility group B proteins facilitate strong estrogen receptor binding to classical and half-site estrogen response elements and relax binding selectivity.
    Mol Endocrinol. 2004 Nov;18(11):2616-32 PMID: 15256536
  110. Cytolytic cells induce HMGB1 release from melanoma cell lines.
    J Leukoc Biol. 2007 Jan;81(1):75-83 PMID: 16968820
  111. Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein.
    Mol Cell Biol. 2002 Oct;22(19):6797-808 PMID: 12215537
  112. Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils.
    J Biol Chem. 2007 Jun 1;282(22):16336-44 PMID: 17403684
  113. The hallmarks of cancer.
    Cell. 2000 Jan 7;100(1):57-70 PMID: 10647931
  114. Expression of receptors for advanced glycation end-products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer.
    J Pathol. 2002 Feb;196(2):163-70 PMID: 11793367
  115. New EMBO members' review: the double life of HMGB1 chromatin protein: architectural factor and extracellular signal.
    EMBO J. 2001 Aug 15;20(16):4337-40 PMID: 11500360
  116. Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells.
    Int J Mol Med. 2007 Aug;20(2):187-92 PMID: 17611636
  117. Receptor for advanced glycation end products (RAGE)--soluble form (sRAGE) and gene polymorphisms in patients with breast cancer.
    Cancer Invest. 2007 Dec;25(8):720-5 PMID: 18058469
  118. HMG-1 stimulates estrogen response element binding by estrogen receptor from stably transfected HeLa cells.
    Mol Endocrinol. 1999 Apr;13(4):632-43 PMID: 10194768
  119. The expression of receptor for advanced glycation end products is associated with angiogenesis in human oral squamous cell carcinoma.
    Virchows Arch. 2007 Mar;450(3):287-95 PMID: 17235565
  120. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.
    Am J Respir Cell Mol Biol. 2009 Dec;41(6):651-60 PMID: 19265175
  121. Involvement of high mobility group B proteins in cisplatin-induced cytotoxicity in squamous cell carcinoma of skin.
    DNA Cell Biol. 2009 Jul;28(7):311-8 PMID: 19435426
  122. Suppression of dendritic cells by HMGB1 is associated with lymph node metastasis of human colon cancer.
    Pathobiology. 2009;76(4):155-62 PMID: 19571604
  123. RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.
    J Transl Med. 2009 Mar 17;7:17 PMID: 19292913
  124. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants.
    Transplantation. 1994 Jan;57(2):211-7 PMID: 8310510
  125. Increased expression of high mobility group box 1 (HMGB1) is associated with an elevated level of the antiapoptotic c-IAP2 protein in human colon carcinomas.
    Gut. 2006 Feb;55(2):234-42 PMID: 16118352
  126. High mobility group protein-1 (HMG-1) is a unique activator of p53.
    Genes Dev. 1998 Feb 15;12(4):462-72 PMID: 9472015
  127. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.
    J Leukoc Biol. 2009 Sep;86(3):633-43 PMID: 19454652
  128. Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes.
    Mol Biol Cell. 2003 Aug;14(8):3414-26 PMID: 12925773
  129. The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice.
    Nat Genet. 1999 Jul;22(3):276-80 PMID: 10391216
  130. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468.
    Cancer Res. 1994 May 1;54(9):2424-8 PMID: 8162591
  131. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation.
    Nature. 2002 Jul 11;418(6894):191-5 PMID: 12110890
  132. Non-histone nuclear factor HMGB1 is phosphorylated and secreted in colon cancers.
    Lab Invest. 2009 Aug;89(8):948-59 PMID: 19506549
  133. Interactions between an HMG-1 protein and members of the Rel family.
    Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10679-83 PMID: 10485885
  134. Dealing with death: HMGB1 as a novel target for cancer therapy.
    Curr Opin Investig Drugs. 2003 Dec;4(12):1405-9 PMID: 14763124
  135. The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity.
    Immunol Rev. 2007 Dec;220:60-81 PMID: 17979840
  136. Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation.
    Cancer Res. 2003 May 1;63(9):2188-93 PMID: 12727838
  137. Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.
    Gut. 2010 Jan;59(1):69-78 PMID: 19828471
  138. Quercetin inhibits LPS-induced delay in spontaneous apoptosis and activation of neutrophils.
    Inflamm Res. 2005 Dec;54(12):500-7 PMID: 16389571
  139. Extracellular role of HMGB1 in inflammation and sepsis.
    J Intern Med. 2004 Mar;255(3):320-31 PMID: 14871456
  140. Synthesis, characterization, and cytotoxicity of a series of estrogen-tethered platinum(IV) complexes.
    Chem Biol. 2004 Apr;11(4):557-64 PMID: 15123250
  141. The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion.
    J Exp Med. 2005 Apr 4;201(7):1135-43 PMID: 15795240
  142. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die.
    Cell Death Differ. 2009 Jan;16(1):175-83 PMID: 18846108
  143. The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival.
    Cell Death Differ. 2010 Apr;17(4):666-76 PMID: 19834494
  144. Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.
    Nat Cell Biol. 2007 Apr;9(4):402-14 PMID: 17384639
  145. Purification and characterization of mouse soluble receptor for advanced glycation end products (sRAGE).
    J Biol Chem. 2004 Nov 26;279(48):50019-24 PMID: 15381690
  146. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1.
    J Leukoc Biol. 2007 Mar;81(3):741-7 PMID: 17135572
  147. Alkylating DNA damage stimulates a regulated form of necrotic cell death.
    Genes Dev. 2004 Jun 1;18(11):1272-82 PMID: 15145826
  148. The inflammatory tumor microenvironment and its impact on cancer development.
    Contrib Microbiol. 2006;13:118-137 PMID: 16627962
  149. Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.
    J Immunol. 2007 Jun 1;178(11):7376-84 PMID: 17513788
  150. Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin.
    Cancer Invest. 2008 Oct;26(8):843-51 PMID: 18798064
  151. Cancer: Inflaming metastasis.
    Nature. 2009 Jan 1;457(7225):36-7 PMID: 19122629
  152. [High mobility group box 1 is increased in children with acute lymphocytic leukemia and stimulates the release of tumor necrosis factor-alpha in leukemic cell].
    Zhonghua Er Ke Za Zhi. 2007 May;45(5):329-33 PMID: 17697615
  153. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.
    EMBO J. 2003 Oct 15;22(20):5551-60 PMID: 14532127
  154. Not just nuclear proteins: 'novel' autophagy cancer treatment targets - p53 and HMGB1.
    Curr Opin Investig Drugs. 2008 Dec;9(12):1259-63 PMID: 19037832
  155. High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine.
    J Immunol. 2008 Sep 15;181(6):4240-6 PMID: 18768881
  156. [Effect of high mobility group box 1 protein on proliferation and apoptosis and balance between Th1/Th2 and Tc1/Tc2 of lymphocytes in vitro].
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2008 Apr;24(4):324-7 PMID: 18394333
  157. [Expression and clinical significance of HMGB1 and RAGE in cervical squamous cell carcinoma].
    Zhonghua Zhong Liu Za Zhi. 2008 Apr;30(4):292-5 PMID: 18788635
Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbagrm.2009.11.014
Published
2010-00-00
Pages
131-40
Language
English
Region
Netherlands
NLM ID
0217513
PMCID
PMC2818552
Subset
IM
Grants
NCI NIH HHS · P01 CA101944 · United States
NCI NIH HHS · P01 CA101944-01A2 · United States
NCI NIH HHS · P01 CA101944-05 · United States
NCI NIH HHS · P30 CA047904-160008 · United States
External Links
PubMed source DOI: 10.1016/j.bbagrm.2009.11.014 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2